Parameter non-identifiability of the Gyllenberg-Webb ODE model.

An ODE model introduced by Gyllenberg and Webb (Growth Develop Aging 53:25-33, 1989) describes tumour growth in terms of the dynamics between proliferating and quiescent cell states. The passage from one state to another and vice versa is modelled by two functions r0 and ri depending on the total tumour size. As these functions do not represent any observable quantities, they have to be identified from the observations. In this paper we show that there is an infinite number of pairs (r0, ri) corresponding to the same solution of the ODE system and the functions (r0, ri) will be classified in terms of this equivalence. Surprisingly, the technique used for this classification permits a uniqueness proof of the solution of the ODE model in a non-Lipschitz case. The reasoning can be widened to a more general setting including an extension of the Gyllenberg-Webb model with a nonlinear birth rate. The relevance of this result is discussed in a preclinical application scenario.