Literature DB >> 23989353

Tissue protection by erythropoietin: new findings in a moving field.

Masaomi Nangaku1.   

Abstract

Two groups elucidate novel mechanisms of tissue protection by erythropoietin (EPO). Hu et al. demonstrate that Klotho's protective effect against oxidant-induced cytotoxicity is partially mediated by an increase in the endogenous expression of the classical EPO receptor (EpoR). While erythropoiesis is stimulated by the canonical EpoR homodimer, the tissue-protective effects of EPO are mediated through a heterodimeric 'tissue-protective' receptor. Coldewey et al. demonstrate a protective role of the 'tissue-protective' EpoR against acute kidney injury.

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Year:  2013        PMID： 23989353     DOI： 10.1038/ki.2013.140

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  11 in total

1.  Carbamylated erythropoietin mediates retinal neuroprotection in streptozotocin-induced early-stage diabetic rats.

Authors:  Xiaojing Liu; Bijun Zhu; Haidong Zou; Daode Hu; Qing Gu; Kun Liu; Xun Xu
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-03-01       Impact factor: 3.117

2.  Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.

Authors:  Mingjun Shi; Brianna Flores; Peng Li; Nancy Gillings; Kathryn L McMillan; Jianfeng Ye; Lily Jun-Shen Huang; Sachdev S Sidhu; Yong-Ping Zhong; Maria T Grompe; Philip R Streeter; Orson W Moe; Ming Chang Hu
Journal:  Am J Physiol Renal Physiol       Date:  2017-11-29

3.  Genetic compensation by epob in pronephros development in epoa mutant zebrafish.

Authors:  Jianqing She; Yue Wu; Bowen Lou; Elisabeth Lodd; Alina Klems; Felix Schmoehl; Zuyi Yuan; Ferdinand Le Noble; Jens Kroll
Journal:  Cell Cycle       Date:  2019-08-26       Impact factor: 4.534

4.  Low Oxygen Tension Primes Aortic Endothelial Cells to the Reparative Effect of Tissue-Protective Cytokines.

Authors:  Lamia Heikal; Pietro Ghezzi; Manuela Mengozzi; Gordon Ferns
Journal:  Mol Med       Date:  2015-09-01       Impact factor: 6.354

5.  Restoration of Haemoglobin Level Using Hydrodynamic Gene Therapy with Erythropoietin Does Not Alleviate the Disease Progression in an Anaemic Mouse Model for TGFβ1-Induced Chronic Kidney Disease.

Authors:  Lea Pedersen; Lise Wogensen; Niels Marcussen; Claudia R Cecchi; Trine Dalsgaard; Frederik Dagnæs-Hansen
Journal:  PLoS One       Date:  2015-06-05       Impact factor: 3.240

Review 6.  Microparticles: markers and mediators of sepsis-induced microvascular dysfunction, immunosuppression, and AKI.

Authors:  Ana Carolina P Souza; Peter S T Yuen; Robert A Star
Journal:  Kidney Int       Date:  2015-02-18       Impact factor: 10.612

7.  Erythropoietin accelerates tumor growth through increase of erythropoietin receptor (EpoR) as well as by the stimulation of angiogenesis in DLD-1 and Ht-29 xenografts.

Authors:  A Tankiewicz-Kwedlo; J Hermanowicz; A Surażynski; D Rożkiewicz; A Pryczynicz; T Domaniewski; K Pawlak; A Kemona; D Pawlak
Journal:  Mol Cell Biochem       Date:  2016-08-20       Impact factor: 3.396

8.  CERA Attenuates Kidney Fibrogenesis in the db/db Mouse by Influencing the Renal Myofibroblast Generation.

Authors:  Christin Fischer; Natalie Deininger; Gunter Wolf; Ivonne Loeffler
Journal:  J Clin Med       Date:  2018-01-30       Impact factor: 4.241

9.  Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor.

Authors:  Megumi Oshima; Akinori Hara; Tadashi Toyama; Min Jun; Carol Pollock; Meg Jardine; Stephen Harrap; Neil Poulter; Mark E Cooper; Mark Woodward; John Chalmers; Vlado Perkovic; Muh Geot Wong; Takashi Wada
Journal:  Kidney Int Rep       Date:  2020-11-10

Review 10.  Erythropoietin Receptor/β Common Receptor: A Shining Light on Acute Kidney Injury Induced by Ischemia-Reperfusion.

Authors:  Yuanyuan Wu; Bin Yang
Journal:  Front Immunol       Date:  2021-06-30       Impact factor: 7.561
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