OBJECTIVES: We aimed to determine the effect of exercise training on plasma levels of brain-derived neurotrophic factor (BDNF), and serum insulin-like growth factor-1 (IGF-1) as well as cAMP response element-binding (CREB) activation in peripheral blood mononuclear cells (PBMCs) in adolescents. METHODS: Nine trained and seven sedentary male adolescents, matched in age (14.0±2.2 years), were recruited for the study. Trained boys performed higher physical activity levels (expressed both as total energy expenditure and as physical activity energy expenditure) and showed significant bradycardia when compared with sedentary ones. RESULTS: We found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones. However, no effect of training was found in the activation of CREB in PBMCs. CONCLUSIONS: We demonstrated the increase of neuroplasticity-related proteins due to exercise training in adolescents. Our results emphasize the significance and impact of exercise in this developmental period.
OBJECTIVES: We aimed to determine the effect of exercise training on plasma levels of brain-derived neurotrophic factor (BDNF), and serum insulin-like growth factor-1 (IGF-1) as well as cAMP response element-binding (CREB) activation in peripheral blood mononuclear cells (PBMCs) in adolescents. METHODS: Nine trained and seven sedentary male adolescents, matched in age (14.0±2.2 years), were recruited for the study. Trained boys performed higher physical activity levels (expressed both as total energy expenditure and as physical activity energy expenditure) and showed significant bradycardia when compared with sedentary ones. RESULTS: We found that BDNF and IGF-1 levels were significantly higher in trained adolescents than in sedentary ones. However, no effect of training was found in the activation of CREB in PBMCs. CONCLUSIONS: We demonstrated the increase of neuroplasticity-related proteins due to exercise training in adolescents. Our results emphasize the significance and impact of exercise in this developmental period.
Authors: Mari Carmen Gomez-Cabrera; Aitor Carretero; Fernando Millan-Domingo; Esther Garcia-Dominguez; Angela G Correas; Gloria Olaso-Gonzalez; Jose Viña Journal: Redox Biol Date: 2021-03-24 Impact factor: 11.799
Authors: María Martinez-Ferran; Fernando de la Guía-Galipienso; Fabián Sanchis-Gomar; Helios Pareja-Galeano Journal: Nutrients Date: 2020-05-26 Impact factor: 5.717
Authors: Adrian De la Rosa; Gloria Olaso-Gonzalez; Coralie Arc-Chagnaud; Fernando Millan; Andrea Salvador-Pascual; Consolacion García-Lucerga; Cristina Blasco-Lafarga; Esther Garcia-Dominguez; Aitor Carretero; Angela G Correas; Jose Viña; Mari Carmen Gomez-Cabrera Journal: J Sport Health Sci Date: 2020-02-04 Impact factor: 7.179