BACKGROUND: The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKR rs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKR rs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population. METHODS: A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKR rs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated. RESULTS: GCKR rs780094 AA genotype was significantly associated with higher TG (p<0.001 vs. GG), lower HDL-C (p=0.021 vs. GG), and lower HbA1c(p=0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p=0.001 vs. GX). These associations were seen only in men. CONCLUSIONS: GCKR rs780094 was associated with TG, HDL-C, and HbA1c levels, as well as with CIMT in Japanese community-dwelling men, but not women.
BACKGROUND: The glucokinase regulator gene (GCKR) rs780094 has been shown to be strongly associated with some metabolic traits and atherosclerotic parameters, while the association between GCKRrs780094 and carotid intima-media thickness (CIMT) has not been fully investigated in the general population. The associations between the GCKRrs780094 genotype and metabolic traits including CIMT were examined in a Japanese community-dwelling population. METHODS: A total of 2491 Japanese adults (907 men and 1584 women) who participated in a medical screening program for the general population from 29 to 94 years of age during 2008 to 2010 were enrolled. GCKRrs780094 was genotyped by the TaqMan polymerase chain reaction method, and associations with metabolic markers including CIMT were evaluated. RESULTS:GCKRrs780094 AA genotype was significantly associated with higher TG (p<0.001 vs. GG), lower HDL-C (p=0.021 vs. GG), and lower HbA1c(p=0.023 vs. GG). The AA genotype showed significantly thinner CIMT (p=0.001 vs. GX). These associations were seen only in men. CONCLUSIONS:GCKRrs780094 was associated with TG, HDL-C, and HbA1c levels, as well as with CIMT in Japanese community-dwelling men, but not women.
Authors: Caren E Smith; Jack L Follis; Jennifer A Nettleton; Millennia Foy; Jason H Y Wu; Yiyi Ma; Toshiko Tanaka; Ani W Manichakul; Hongyu Wu; Audrey Y Chu; Lyn M Steffen; Myriam Fornage; Dariush Mozaffarian; Edmond K Kabagambe; Luigi Ferruci; Yii-Der Ida Chen; Stephen S Rich; Luc Djoussé; Paul M Ridker; Weihong Tang; Barbara McKnight; Michael Y Tsai; Stefania Bandinelli; Jerome I Rotter; Frank B Hu; Daniel I Chasman; Bruce M Psaty; Donna K Arnett; Irena B King; Qi Sun; Lu Wang; Thomas Lumley; Stephanie E Chiuve; David S Siscovick; José M Ordovás; Rozenn N Lemaitre Journal: Mol Nutr Food Res Date: 2015-03-16 Impact factor: 6.575
Authors: Luigi Castaldo; Federica Laguzzi; Rona J Strawbridge; Damiano Baldassarre; Fabrizio Veglia; Lorenzo Vigo; Elena Tremoli; Ulf de Faire; Per Eriksson; Andries J Smit; Jiri Aubrecht; Karin Leander; Matteo Pirro; Philippe Giral; Alberto Ritieni; Giovanni Di Minno; Anders Mälarstig; Bruna Gigante Journal: Genes (Basel) Date: 2020-10-22 Impact factor: 4.096