Literature DB >> 23989101

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.

Nojoon Myung1, Stephen Connelly2, Boyoung Kim1, Sung Jean Park3, Ian A Wilson2, Jeffery W Kelly4, Sungwook Choi1.   

Abstract

We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off-on fluorescent sensing of the properly folded quaternary structure of TTR.

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Year:  2013        PMID： 23989101      PMCID： PMC4061458          DOI： 10.1039/c3cc44667k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  38 in total

Review 1.  Protein folding and misfolding.

Authors:  Christopher M Dobson
Journal:  Nature       Date:  2003-12-18       Impact factor: 49.962

2.  Labeling of fusion proteins with synthetic fluorophores in live cells.

Authors:  Antje Keppler; Horst Pick; Claudio Arrivoli; Horst Vogel; Kai Johnsson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-28       Impact factor: 11.205

3.  A stilbene that binds selectively to transthyretin in cells and remains dark until it undergoes a chemoselective reaction to create a bright blue fluorescent conjugate.

Authors:  Sungwook Choi; Derrick Sek Tong Ong; Jeffery W Kelly
Journal:  J Am Chem Soc       Date:  2010-10-21       Impact factor: 15.419

Review 4.  Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

Authors:  Steven M Johnson; R Luke Wiseman; Yoshiki Sekijima; Nora S Green; Sara L Adamski-Werner; Jeffery W Kelly
Journal:  Acc Chem Res       Date:  2005-12       Impact factor: 22.384

5.  A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Authors:  Sungwook Choi; Natàlia Reixach; Stephen Connelly; Steven M Johnson; Ian A Wilson; Jeffery W Kelly
Journal:  J Am Chem Soc       Date:  2010-02-03       Impact factor: 15.419

6.  Analyses of prealbumin mRNAs in individuals with familial amyloidotic polyneuropathy.

Authors:  S Mita; S Maeda; K Shimada; S Araki
Journal:  J Biochem       Date:  1986-11       Impact factor: 3.387

7.  Structure of a complex of two plasma proteins: transthyretin and retinol-binding protein.

Authors:  H L Monaco; M Rizzi; A Coda
Journal:  Science       Date:  1995-05-19       Impact factor: 47.728

8.  Green fluorescent protein as a marker for gene expression.

Authors:  M Chalfie; Y Tu; G Euskirchen; W W Ward; D C Prasher
Journal:  Science       Date:  1994-02-11       Impact factor: 47.728

9.  Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Authors:  Steven M Johnson; Stephen Connelly; Ian A Wilson; Jeffery W Kelly
Journal:  J Med Chem       Date:  2009-02-26       Impact factor: 7.446

10.  Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution.

Authors:  A Wojtczak; V Cody; J R Luft; W Pangborn
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1996-07-01
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  3 in total

1.  Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts.

Authors:  Yu Liu; Yun Lei Tan; Xin Zhang; Gira Bhabha; Damian C Ekiert; Joseph C Genereux; Younhee Cho; Yakov Kipnis; Sinisa Bjelic; David Baker; Jeffery W Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-03       Impact factor: 11.205

2.  Expression of Transthyretin during bovine myogenic satellite cell differentiation.

Authors:  Smritee Pokharel; Majid Rasool Kamli; Bilal Ahmad Mir; Adeel Malik; Eun Ju Lee; Inho Choi
Journal:  In Vitro Cell Dev Biol Anim       Date:  2014-06-06       Impact factor: 2.416

3.  Transthyretin: A Transporter Protein Essential for Proliferation of Myoblast in the Myogenic Program.

Authors:  Eun Ju Lee; Smritee Pokharel; Arif Tasleem Jan; Soyeon Huh; Richelle Galope; Jeong Ho Lim; Dong-Mok Lee; Sung Wook Choi; Sang-Soep Nahm; Yong-Woon Kim; So-Young Park; Inho Choi
Journal:  Int J Mol Sci       Date:  2017-01-08       Impact factor: 5.923
  3 in total

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