BACKGROUND/ OBJECTIVE: Psoriatic nail disease is increasingly recognised to be of major clinical and research relevance. Clinical assessment remains the current gold standard for its evaluation. OBJECTIVE: We compared optical coherence tomography (OCT) and ultrasound (US) for nail disease assessment in psoriatic disease. METHODS: 18 patients with at least one involved nail and 12 healthy controls were scanned using OCT; psoriatic patients also had an US scan (using a linear probe at 9-14 MHz). Nail and contour abnormalities were documented. Clinical onychopathy was scored independently using the modified Nail Psoriasis Severity Index. RESULTS: Among 180 nails, 67.8% had clinical findings whereas 33.9% were abnormal by US and 44.4% had abnormalities on OCT. A positive OCT had a sensitivity and specificity of 44.4 and 95.8%, respectively, with a positive likelihood ratio of 10.7 for nail disease. OCT demonstrated 76.3% absolute agreement compared with clinical assessment and 65% with US. OCT detected subtle abnormalities in 12 clinically normal nails and in 41 nails with normal US findings. CONCLUSION: These findings show that OCT has a potential for the systematic characterisation of psoriatic nail changes and could be useful in diagnosis and more objective assessment of treatment response.
BACKGROUND/ OBJECTIVE:Psoriatic nail disease is increasingly recognised to be of major clinical and research relevance. Clinical assessment remains the current gold standard for its evaluation. OBJECTIVE: We compared optical coherence tomography (OCT) and ultrasound (US) for nail disease assessment in psoriatic disease. METHODS: 18 patients with at least one involved nail and 12 healthy controls were scanned using OCT; psoriaticpatients also had an US scan (using a linear probe at 9-14 MHz). Nail and contour abnormalities were documented. Clinical onychopathy was scored independently using the modified Nail Psoriasis Severity Index. RESULTS: Among 180 nails, 67.8% had clinical findings whereas 33.9% were abnormal by US and 44.4% had abnormalities on OCT. A positive OCT had a sensitivity and specificity of 44.4 and 95.8%, respectively, with a positive likelihood ratio of 10.7 for nail disease. OCT demonstrated 76.3% absolute agreement compared with clinical assessment and 65% with US. OCT detected subtle abnormalities in 12 clinically normal nails and in 41 nails with normal US findings. CONCLUSION: These findings show that OCT has a potential for the systematic characterisation of psoriatic nail changes and could be useful in diagnosis and more objective assessment of treatment response.
Authors: Adam S Aldahan; Lucy L Chen; Raymond M Fertig; Jon Holmes; Vidhi V Shah; Stephanie Mlacker; Vincent M Hsu; Keyvan Nouri; Antonella Tosti Journal: Skin Appendage Disord Date: 2016-09-21
Authors: Elisa de Oliveira Barcaui; Antonio Carlos Pires Carvalho; Flavia Paiva Proença Lobo Lopes; Juan Piñeiro-Maceira; Carlos Baptista Barcaui Journal: An Bras Dermatol Date: 2016 May-Jun Impact factor: 1.896
Authors: Garifallia Sakellariou; Carlo Alberto Scirè; Antonella Adinolfi; Alberto Batticciotto; Alessandra Bortoluzzi; Andrea Delle Sedie; Orazio De Lucia; Christian Dejaco; Oscar Massimiliano Epis; Emilio Filippucci; Luca Idolazzi; Andrea Picchianti Diamanti; Alen Zabotti; Annamaria Iagnocco; Georgios Filippou Journal: Front Med (Lausanne) Date: 2020-05-07