Literature DB >> 23988353

Evaluation of the Influence of thiosemicarbazone-triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents.

Henok H Kinfe1, Yonas H Belay, Jitcy S Joseph, Emmanuel Mukwevho.   

Abstract

A series of thiosemicarbazone-triazole hybrids 1a-h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Diabetics; Lipid; Obesity; Thiosemicarbazon–triazole hybrid

Mesh：

Substances：

Year:  2013        PMID： 23988353     DOI： 10.1016/j.bmcl.2013.08.028

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis and SPAR exploration of new semicarbazone-triazole hybrids in search of potent antioxidant, antibacterial and antifungal agents.

Authors:  Jihed Brahmi; Sana Bakari; Soumaya Nasri; Habib Nasri; Adel Kadri; Kaïss Aouadi
Journal:  Mol Biol Rep       Date:  2018-12-03       Impact factor: 2.316

2.  Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors.

Authors:  Renjitha Jalaja; Shyni G Leela; Praveen K Valmiki; Chettiyan Thodi F Salfeena; Kizhakkan T Ashitha; Venkata Rao D Krishna Rao; Mangalam S Nair; Raghu K Gopalan; Sasidhar B Somappa
Journal:  ACS Med Chem Lett       Date:  2018-06-18       Impact factor: 4.345

3.  New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo.

Authors:  Tian-Yi Zhang; Chun-Shi Li; Li-Ting Cao; Xue-Qian Bai; Dong-Hai Zhao; Si-Mei Sun
Journal:  Mol Divers       Date:  2021-06-02       Impact factor: 2.943

4.  Evaluation of free radical scavenging capacity of methoxy containing-hybrids of thiosemicarbazone-triazole and their influence on glucose transport.

Authors:  Ademola O Ayeleso; Jitcy S Joseph; Oluwafemi O Oguntibeju; Emmanuel Mukwevho
Journal:  BMC Pharmacol Toxicol       Date:  2018-12-06       Impact factor: 2.483
  4 in total

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