Literature DB >> 23987066

[Conotoxins: from the biodiversity of gastropods to new drugs].

A É Fedosov, S A Moshkovskiĭ, K G Kuznetsova, B M Olivera.   

Abstract

A review describes general trends in research of conotoxins that are peptide toxins isolated from sea gastropods of the Conus genus, since the toxins were discovered in 1970th. There are disclosed a conotoxin classification, their structure diversity and different ways of action to their molecular targets, mainly, ion channels. In the applied aspect of conotoxin research, drug discovery and development is discussed, the drugs being based on conotoxin structure. A first exemplary drug is a ziconotide, which is an analgesic of new generation.

Entities:  

Mesh:

Substances:

Year:  2013        PMID: 23987066     DOI: 10.18097/pbmc20135903267

Source DB:  PubMed          Journal:  Biomed Khim        ISSN: 2310-6905


  4 in total

1.  Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system.

Authors:  Camila Franco Batista Oliveira; Daniela Pereira Alves; Bruna Luiza Emerich; Suely Gomes de Figueiredo; Marta do Nascimento Cordeiro; Márcia Helena Borges; Michael Richardson; Adriano Monteiro de Castro Pimenta; Igor Dimitri Gama Duarte; Maria Elena de Lima
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2019-08-12

2.  A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail Conus fergusoni, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors.

Authors:  Ximena C Rodriguez-Ruiz; Manuel B Aguilar; Mónica A Ortíz-Arellano; Helena Safavi-Hemami; Estuardo López-Vera
Journal:  Toxins (Basel)       Date:  2022-07-26       Impact factor: 5.075

3.  Scorpion Toxin, BmP01, Induces Pain by Targeting TRPV1 Channel.

Authors:  Md Abdul Hakim; Wenbin Jiang; Lei Luo; Bowen Li; Shilong Yang; Yuzhu Song; Ren Lai
Journal:  Toxins (Basel)       Date:  2015-09-14       Impact factor: 4.546

Review 4.  Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery.

Authors:  Bingmiao Gao; Chao Peng; Jiaan Yang; Yunhai Yi; Junqing Zhang; Qiong Shi
Journal:  Toxins (Basel)       Date:  2017-12-07       Impact factor: 4.546

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.