Literature DB >> 23986270

Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy.

Nirmalya Bag1, Ashraf Ali, Virander Singh Chauhan, Thorsten Wohland, Aseem Mishra.   

Abstract

Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity.

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Year:  2013        PMID： 23986270     DOI： 10.1039/c3cc44880k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Imaging fluorescence (cross-) correlation spectroscopy in live cells and organisms.

Authors:  Jan W Krieger; Anand P Singh; Nirmalya Bag; Christoph S Garbe; Timothy E Saunders; Jörg Langowski; Thorsten Wohland
Journal:  Nat Protoc       Date:  2015-11-05       Impact factor: 13.491

2.  Bayesian total internal reflection fluorescence correlation spectroscopy reveals hIAPP-induced plasma membrane domain organization in live cells.

Authors:  Syuan-Ming Guo; Nirmalya Bag; Aseem Mishra; Thorsten Wohland; Mark Bathe
Journal:  Biophys J       Date:  2014-01-07       Impact factor: 4.033

3.  Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.

Authors:  Marie E Oskarsson; Kailash Singh; Jian Wang; Israel Vlodavsky; Jin-Ping Li; Gunilla T Westermark
Journal:  J Biol Chem       Date:  2015-04-28       Impact factor: 5.157

Review 4.  Factors That Contribute to hIAPP Amyloidosis in Type 2 Diabetes Mellitus.

Authors:  Adriana Sevcuka; Kenneth White; Cassandra Terry
Journal:  Life (Basel)       Date:  2022-04-14

5.  Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.

Authors:  Yanting Xing; Emily H Pilkington; Miaoyi Wang; Cameron J Nowell; Aleksandr Kakinen; Yunxiang Sun; Bo Wang; Thomas P Davis; Feng Ding; Pu Chun Ke
Journal:  Phys Chem Chem Phys       Date:  2017-11-22       Impact factor: 3.676

6.  Plasma Membrane Organization of Epidermal Growth Factor Receptor in Resting and Ligand-Bound States.

Authors:  Nirmalya Bag; Shuangru Huang; Thorsten Wohland
Journal:  Biophys J       Date:  2015-11-03       Impact factor: 4.033

7.  Heptanol-mediated phase separation determines phase preference of molecules in live cell membranes.

Authors:  Anjali Gupta; Danqin Lu; Harikrushnan Balasubramanian; Zhang Chi; Thorsten Wohland
Journal:  J Lipid Res       Date:  2022-04-28       Impact factor: 6.676

Review 8.  Human islet amyloid polypeptide: A therapeutic target for the management of type 2 diabetes mellitus.

Authors:  Pratiksha H Roham; Shreyada N Save; Shilpy Sharma
Journal:  J Pharm Anal       Date:  2022-04-07

Review 9.  The Effects of Lipid Membranes, Crowding and Osmolytes on the Aggregation, and Fibrillation Propensity of Human IAPP.

Authors:  Mimi Gao; Roland Winter
Journal:  J Diabetes Res       Date:  2015-10-25       Impact factor: 4.011
  9 in total

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