Literature DB >> 23986133

Novel porphyrin-psoralen conjugates: synthesis, DNA interaction and cytotoxicity studies.

Dalip Kumar1, Bhupendra A Mishra, K P Chandra Shekar, Anil Kumar, Kanako Akamatsu, Ryohsuke Kurihara, Takeo Ito.   

Abstract

A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC50 = 84 nM).

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Year:  2013        PMID: 23986133     DOI: 10.1039/c3ob41224e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  1 in total

1.  Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives.

Authors:  Sai Fang; Lei Chen; Miao Yu; Bao Cheng; Yongsheng Lin; Susan L Morris-Natschke; Kuo-Hsiung Lee; Qiong Gu; Jun Xu
Journal:  Org Biomol Chem       Date:  2015-04-28       Impact factor: 3.876

  1 in total

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