| Literature DB >> 23984915 |
Philip J Rushworth1, David G Hulcoop, David J Fox.
Abstract
Tetramethylethylenediamine (TMEDA) acts as cheap and readily removed ligand in the iron-catalyzed coupling of alkyl Grignard reagents and activated aryl chlorides. The use of TMEDA allows for low ligand and iron catalyst loading as well as an increased reaction concentration and an ambient reaction temperature on a mole scale.Entities:
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Year: 2013 PMID： 23984915 DOI： 10.1021/jo4016612
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354