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Literature DB >> 2398466

Cytotoxic effects of food additives and pharmaceuticals on cells in culture as determined with the neutral red assay.

Abstract

The acute cytotoxicity of butylated hydroxytoluene and butylated hydroxyanisole to cultured human dermal fibroblasts, keratinocytes, melanocytes, and melanoma tumor cells was determined with the neutral red assay. For all cell types, butylated hydroxytoluene proved to be more cytotoxic than butylated hydroxyanisole. The neutral red assay is a rapid, economical, semiautomated assay that can be used with a variety of cell types in culture to provide quantitated data that can be used to rank test agents according to their potencies.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2398466 DOI： 10.1002/jps.2600790709

Source DB: PubMed Journal: J Pharm Sci ISSN： 0022-3549 Impact factor: 3.534

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Cited

8 in total

1. Neutral red assay for measurement of quantitative vero cell cytotoxicity.

Authors: A Valdivieso-Garcia; R C Clarke; K Rahn; A Durette; D L Macleod; C L Gyles
Journal: Appl Environ Microbiol Date: 1993-06 Impact factor: 4.792

2. Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells.

Authors: Petra Brenerová; Timo Hamers; Jorke H Kamstra; Jan Vondráček; Simona Strapáčová; Patrik L Andersson; Miroslav Machala
Journal: Environ Sci Pollut Res Int Date: 2015-06-17 Impact factor: 4.223

3. Butylated hydroxyanisole inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis and GSH depletion.

Authors: Hwa Jin Moon; Woo Hyun Park
Journal: Mol Cell Biochem Date: 2010-11-27 Impact factor: 3.396

4. Longer-term and short-term variability in pollution of fluvial sediments by dioxin-like and endocrine disruptive compounds.

Authors: P Macikova; T Kalabova; J Klanova; P Kukucka; J P Giesy; K Hilscherova
Journal: Environ Sci Pollut Res Int Date: 2013-12-22 Impact factor: 4.223

5. Comparison of the cytotoxicities of Fusarium metabolites and Alternaria metabolite AAL-toxin to cultured mammalian cell lines.

Authors: R F Vesonder; H Gasdorf; R E Peterson
Journal: Arch Environ Contam Toxicol Date: 1993-05 Impact factor: 2.804

Cytotoxic effects of food additives and pharmaceuticals on cells in culture as determined with the neutral red assay.

1. Neutral red assay for measurement of quantitative vero cell cytotoxicity.

2. Pure non-dioxin-like PCB congeners suppress induction of AhR-dependent endpoints in rat liver cells.

3. Butylated hydroxyanisole inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis and GSH depletion.

4. Longer-term and short-term variability in pollution of fluvial sediments by dioxin-like and endocrine disruptive compounds.

5. Comparison of the cytotoxicities of Fusarium metabolites and Alternaria metabolite AAL-toxin to cultured mammalian cell lines.

Review 6. The in vitro toxicology of Swedish snus.

7. Toxic evaluation of organic extracts from airborne particulate matter in Puerto Rico.

8. Calcitriol modulates the effects of bone marrow-derived mesenchymal stem cells on macrophage functions.