Literature DB >> 23984442

EMI1, a three-in-one ubiquitylation inhibitor.

Hiroyuki Yamano.   

Abstract

The anaphase-promoting complex/cyclosome (APC/C) is restricted by metazoan protein early mitotic inhibitor 1 (EMI1), a natural, potent inhibitor. New findings suggest that the multimodal inhibitory mechanisms of EMI1 control APC/C-dependent ubiquitylation.

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Year:  2013        PMID： 23984442     DOI： 10.1038/nsmb.2626

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  13 in total

1.  Protein-linked ubiquitin chain structure restricts activity of deubiquitinating enzymes.

Authors:  Jonathan B Schaefer; David O Morgan
Journal:  J Biol Chem       Date:  2011-11-09       Impact factor: 5.157

Review 2.  Structure, function and mechanism of the anaphase promoting complex (APC/C).

Authors:  David Barford
Journal:  Q Rev Biophys       Date:  2010-11-22       Impact factor: 5.318

3.  The APC/C inhibitor, Emi1, is essential for prevention of rereplication.

Authors:  Yuichi J Machida; Anindya Dutta
Journal:  Genes Dev       Date:  2007-01-15       Impact factor: 11.361

4.  UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

Authors:  Tao Wu; Yifat Merbl; Ying Huo; Jennifer L Gallop; Amit Tzur; Marc W Kirschner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-06       Impact factor: 11.205

5.  Identification of a physiological E2 module for the human anaphase-promoting complex.

Authors:  Adam Williamson; Katherine E Wickliffe; Barbara G Mellone; Ling Song; Gary H Karpen; Michael Rape
Journal:  Proc Natl Acad Sci U S A       Date:  2009-10-12       Impact factor: 11.205

6.  Emi2-mediated inhibition of E2-substrate ubiquitin transfer by the anaphase-promoting complex/cyclosome through a D-box-independent mechanism.

Authors:  Wanli Tang; Judy Qiju Wu; Chen Chen; Chih-Sheng Yang; Jessie Yanxiang Guo; Christopher D Freel; Sally Kornbluth
Journal:  Mol Biol Cell       Date:  2010-06-09       Impact factor: 4.138

7.  APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.

Authors:  Nevena V Dimova; Nathaniel A Hathaway; Byung-Hoon Lee; Donald S Kirkpatrick; Marie Lea Berkowitz; Steven P Gygi; Daniel Finley; Randall W King
Journal:  Nat Cell Biol       Date:  2012-01-29       Impact factor: 28.824

8.  UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.

Authors:  Mathew J Garnett; Jörg Mansfeld; Colin Godwin; Takahiro Matsusaka; Jiahua Wu; Paul Russell; Jonathon Pines; Ashok R Venkitaraman
Journal:  Nat Cell Biol       Date:  2009-10-11       Impact factor: 28.824

9.  Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail.

Authors:  Munemichi Ohe; Yoshiko Kawamura; Hiroyuki Ueno; Daigo Inoue; Yoshinori Kanemori; Chiharu Senoo; Michitaka Isoda; Nobushige Nakajo; Noriyuki Sagata
Journal:  Mol Biol Cell       Date:  2010-01-20       Impact factor: 4.138

10.  Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

Authors:  Jeremiah J Frye; Nicholas G Brown; Georg Petzold; Edmond R Watson; Christy R R Grace; Amanda Nourse; Marc A Jarvis; Richard W Kriwacki; Jan-Michael Peters; Holger Stark; Brenda A Schulman
Journal:  Nat Struct Mol Biol       Date:  2013-05-26       Impact factor: 15.369
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  4 in total

1.  The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers.

Authors:  Antonio Marzio; Joseph Puccini; Youngho Kwon; Natalia K Maverakis; Arnaldo Arbini; Patrick Sung; Dafna Bar-Sagi; Michele Pagano
Journal:  Mol Cell       Date:  2018-12-13       Impact factor: 17.970

Review 2.  The role of Fbxo5 in the development of human malignant tumors.

Authors:  Junjie Gao; Dandan Yang; Ruoxue Cao; Hua Huang; Jia Ma; Zhiwei Wang; Jun Xia; Xueshan Pan
Journal:  Am J Cancer Res       Date:  2022-04-15       Impact factor: 5.942

3.  Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells.

Authors:  Dina Moustafa; Maha R Abd Elwahed; Hanaa H Elsaid; Jeffrey D Parvin
Journal:  PLoS One       Date:  2021-01-07       Impact factor: 3.240

4.  The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylation.

Authors:  Shisako Shoji; Yutaka Muto; Mariko Ikeda; Fahu He; Kengo Tsuda; Noboru Ohsawa; Ryogo Akasaka; Takaho Terada; Motoaki Wakiyama; Mikako Shirouzu; Shigeyuki Yokoyama
Journal:  FEBS Open Bio       Date:  2014-07-05       Impact factor: 2.693
  4 in total

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