| Literature DB >> 2398361 |
J Gottfries1, P Fredman, J E Månsson, V P Collins, H von Holst, D D Armstrong, A K Percy, C J Wikstrand, D D Bigner, L Svennerholm.
Abstract
The ganglioside composition of six human medulloblastomas was analyzed. The characterization was performed by thin-layer chromatography, sialidase hydrolysis, and immunological staining with a panel of characterized antiganglioside monoclonal antibodies. The total ganglioside content ranged from 60 to 1,130 nmol of ganglioside sialic acid/g wet weight. Neuronal gangliosides (gangliotetraose series) were found in varying amounts in all medulloblastomas. Gangliosides of the neolactotetraose series (3'-LM1 and LD1) were present in all specimens, and the lactotetraose series ganglioside 3'-isoLM1 was found in all cases showing astrocytic differentiation. This supports our previous findings that 3'-isoLM1 is a marker for proliferating astroglial cells.Entities:
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Year: 1990 PMID： 2398361 DOI： 10.1111/j.1471-4159.1990.tb03142.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372