Clustering patterns of comorbidities associated with in-hospital death in hospitalizations of US adults with venous thromboembolism.

BACKGROUND: Venous thromboembolism (VTE) is a significant source of mortality, morbidity, disability, and impaired health-related quality of life in the world.
OBJECTIVE: We aimed to evaluate the clustering patterns and associations of 29 comorbidities with in-hospital death among adult hospitalizations with a diagnosis of VTE in the United States by analyzing data from the 2009 Nationwide Inpatient Sample.
METHODS: This cross-sectional study included 153,124 adult hospitalizations with a diagnosis of VTE. Adjusted rate ratios and 95% confidence intervals (CI) for in-hospital death were generated by using multivariable log-linear regression models to measure independent associations between comorbidities and in-hospital death.
RESULTS: We estimated that 44,200 in-hospital deaths occurred in 2009 among 773,273 US adult hospitalizations with a diagnosis of VTE. Subgroups of hospitalizations with comorbidities of "congestive heart failure," "chronic pulmonary disease," "coagulopathy," "liver disease," "lymphoma," "fluid and electrolyte disorders," "metastatic cancer," "peripheral vascular disorders," "pulmonary circulation disorders," "renal failure," "solid tumor without metastasis," or "weight loss" were positively and independently associated with 1.07 (95% CI: 1.02-1.12 ) to 2.06 (95% CI: 1.97-2.16) times increased likelihoods of in-hospital death, when compared to those without the corresponding comorbidities. The clustering patterns of these comorbidities by 4 disease categories (i.e., "cancer," "cardiovascular/respiratory/blood," "gastrointestinal/urologic," and "nutritional/bodyweight") were associated with 2.74 to 10.28 times increased likelihoods of in-hospital death, as compared to hospitalizations without any of these comorbidities. The overall increase in the cumulative number of comorbidities corresponded to significantly elevated risks (P-trend<0.01) for in-hospital death among hospitalizations with a diagnosis of VTE.
CONCLUSION: The presence of multiple comorbidities is ubiquitous among hospitalizations of adults with VTE and among in-hospital deaths with VTE in the United States. The findings of our study further suggest that, among hospitalizations of adults with VTE, the presence of certain comorbidities or clustering of these comorbidities significantly elevates the risk of in-hospital death.

Introduction

Venous thromboembolism (VTE), presenting clinically as pulmonary embolism or deep vein thrombosis, and its long-term sequelae of post-thrombotic syndrome and chronic thromboembolic pulmonary hypertension are significant sources of mortality, morbidity, disability, and impaired health-related quality of life in the world 1-4. From the classic Virchow's triad (i.e., vascular endothelial damage, stasis of blood flow, and hypercoagulability of blood) to the current classification scheme of unprovoked (e.g., idiopathic) and provoked (e.g., secondary) VTE resulting from transient (e.g., fractures) or persistent risk factors (e.g., cancer) 5-7, research over the past several decades has unveiled that VTE is a multifaceted disease affecting individuals across various socio-demographic groups 4, 7, 8.

A previous study reported that, among patients with a confirmed episode of VTE, about 74% developed VTE in the outpatient setting and 37% of such outpatients had a recent hospitalization in the preceding 3 months 9. Recent data from the National Hospital Discharge Survey linked VTE to more than half a million US adult hospitalizations annually during 2007-2009 10. The risk of VTE and its prognostic health consequences increase with age and are associated with comorbidity—the presence of additional disease in relation to an index disease such as VTE 4, 11-14. Advances in healthcare research demonstrate that comorbidities can affect one or more diseases through the etiological mechanisms of direct causation (e.g., disease A is directly responsible for disease B), associated risk factors (e.g., correlated risk factors make concurrent diseases more likely to occur), heterogeneity (e.g., independent risk factors for either disease), and independence (e.g., some diagnostic features of the co-occurring diseases actually correspond to a third distinct disease) 11. An increasing body of research shows that comorbidities may confound clinical assessment 15, 16, hinder timely diagnosis 17, and aggravate complications and recurrence 18-21, thereby placing patients with VTE at heightened risks for many debilitating health consequences including death 19.

To date, numerous studies have identified a myriad of biological, behavioral, health, and environmental risk factors that are independently associated with risk of developing VTE 4-8. Yet, limited research has been conducted to evaluate the joint impact of VTE and various medical illnesses on mortality in hospitalized patients with VTE. To the best of our knowledge, no study has evaluated the pattern and concurrent impacts of comorbidities on in-hospital death among US adult hospitalizations with VTE. Therefore, this study aimed to evaluate the clustering patterns and associations of comorbidities with in-hospital death among adult hospitalizations with a diagnosis of VTE in the United States by analyzing data from the 2009 Nationwide Inpatient Sample (NIS).

Materials and methods

Data Source

The NIS is part of the Healthcare Cost and Utilization Project sponsored by the Agency for Healthcare Research and Quality (AHRQ). It is the largest all-payer inpatient care database and includes 5-8 million annual unweighted hospitalizations of patients covered by Medicare, Medicaid, private insurance, and the uninsured from about 1,000 community hospitals in the United States. The NIS is designed to approximate a 20% sample of US community hospitals; all hospitalizations from sampled hospitals are included in the NIS 22. The NIS sampling frame consists of non-federal, short-term, general, specialty hospitals, and long-term acute care facilities. Excluded from the NIS are short-term rehabilitation hospitals, long-term non-acute care hospitals, psychiatric hospitals, and alcoholism/chemical dependency treatment facilities 22. Details about the sampling methodology are described elsewhere 23. All sampling procedures involving human subjects and confidentiality were reviewed and approved by the Research Ethics Review Board of the AHRQ 23. The 2009 Inpatient Core file contains data for 7,810,762 hospitalizations drawn from 1,050 hospitals of participating states that comprise 96% of the US population.

Inpatient Sample

Each sampled hospitalization in the NIS includes a maximum of 25 diagnostic codes based on the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). VTE was identified using ICD-9-CM codes 415.1x, 451.1x, 451.2, 451.8x, 451.9, 453.2, 453.4x, 453.8x, and 453.9 in any of the diagnostic fields. We limited our analysis to an unweighted sample of hospitalizations for adults aged 18 years and older with a diagnosis of VTE (n=154,047). We excluded hospitalizations related to pregnancy, childbirth, and puerperium of patients who are mostly young, who have a low incidence of comorbidities and VTE, and who have a small risk of death during hospitalization, although the risk of developing VTE may be increased during pregnancy and postpartum period 24-27. After excluding hospitalizations due to pregnancy, childbirth, and puerperium and variables with missing information for sex, vital status, length of hospital stay, or status of primary expected payer, 153,124 unweighted hospitalizations were included in the analyses.

Demographic, Clinical, and Insurance Characteristics

The demographic variables included age, sex, and race/ethnicity (15% missing data). Because of potential misclassification and some participating states do not report race/ethnicity information, national estimates for race/ethnicity should be interpreted with caution. In addition, we included clinical characteristics and insurance status (i.e., days of hospital stay, insurance status of primary expected payer, and status of operating room procedure) as covariates, because of their relevance to the outcome and prevention of VTE. The NIS assigns all ICD-9-CM procedure codes to 4 broad categories of minor diagnostic, minor therapeutic, major diagnostic, and major therapeutic according to the AHRQ Procedure Classes 28. An operating room procedure is defined in the NIS as having at least one major diagnostic or major therapeutic procedure during hospitalization 29.

Comorbidity

Comorbidities are considered in the NIS as coexisting medical conditions that are not directly related to the principal diagnosis or the main reason for admission, and are likely to have originated prior to the hospital stay 30. Charlson et al and Elixhauser et al developed two well-known comorbidity indices for risk adjustment in health outcomes research 24, 25. Lately, the Elixhauser comorbidity index has been found superior for risk adjustment and has been increasingly used in administrative datasets 31-34. While the original Elixhauser comorbidity index contained 30 comorbidities based on ICD-9-CM coding algorithms for diagnoses and diagnosis-related group, the NIS included 29-comorbidity variables excluding “cardiac arrhythmias” 25, 30. We constructed an ordinal variable to indicate the total number of AHRQ comorbidities for each hospitalization and categorized the variable into groups with 1, 2, 3, 4, 5 or more comorbidities.

Statistical Analysis

We calculated the percentage distribution and case-fatality rates of adult hospitalizations with a diagnosis of VTE stratified by age, sex, race/ethnicity, days of hospital stay, insurance status of primary expected payer, operating room procedure, and number of comorbidities. Regardless of actual causes of death, we defined the case-fatality rate in this study as the percentage of hospitalizations of patients with a VTE diagnosis who died during the study period 35. We estimated the number of deaths with a diagnosis of VTE overall in 2009 and by number of comorbidities. We calculated the prevalence of each of the 29 comorbidities among adult hospitalizations. To identify comorbidities that were independently associated with in-hospital death in the study sample, we employed a backward elimination procedure to remove any explanatory variable with the highest P ≥ 0.05 for individual t-test of null hypothesis β=0. The same procedure was repeated until P < 0.05 for all explanatory variables remaining in the final model. Adjusted rate ratios (aRRs) and 95% confidence intervals (CI) for in-hospital death were generated by using multivariate log-linear regression models to measure independent associations between remaining comorbidities and in-hospital death while controlling for age, sex, race/ethnicity, days of hospital stay, primary expected payer, and status of operating room procedure. We calculated the rate ratios for in-hospital death by number of comorbidities and by cumulative severity scores among adult hospitalizations with VTE. We assessed the distribution of 16 clustering patterns for 12 comorbidities by 4 disease categories (i.e., “cancer,” “cardiovascular/respiratory/blood,” “gastrointestinal/urologic,” and “nutritional/bodyweight”) and calculated adjusted rate ratios (aRRs) for in-hospital death among adult hospitalizations with a diagnosis of VTE. We performed orthogonal polynomial contrasts to test linear and quadratic trends to indicate the increase or decrease of aRRs across the categories of comorbidity while controlling for covariates. We performed the data management and analysis using SPSS 18 Complex Samples for Survey Analysis (IBM Corp) and STATA 11 (StataCorp LP) to account for multiple stages of sampling, weighting, stratification, and clustering. All estimates in this study were weighted unless otherwise noted as unweighted sample size (n).

Results

We estimated that 44,200 in-hospital deaths occurred in 2009 among adult hospitalizations with a diagnosis of VTE in the United States, representing an overall case-fatality rate of 5.7%. Approximately 97.9% of these deaths had at least 1 comorbidity (Figure 1). The case-fatality rates varied significantly by age, sex, race/ethnicity, days of hospital stay, insurance status of primary expected payer, status of operating room procedure, and the number of comorbidities (P< 0.001) (Table 1). For instance, large percentages of hospitalizations with VTE were observed among subgroups for patients who were 50-79 years of age, female, white, less than 7 days of hospital stay, or with “no procedure of any kind.” However, high case-fatality rates were observed among subgroups with 80 years and older, male, Asian or other race/ethnicity, or “non-operating room procedure.” Additionally, the case-fatality rates were higher among subgroups of patients whose primary expected payer was Medicare or who had at least 5 comorbidities than among those with other insurance payers or with fewer number of comorbidities (P< 0.001) (Table 1).

Figure 1

Percentage distribution of estimated number of in-hospital deaths with VTE by status of comorbidity, NIS, 2009

Table 1

Percentage distribution and case-fatality rates of adult hospitalizations with a diagnosis of VTE by demographic and clinical characteristics, NIS, 2009

Characteristics	Unweightedn	Estimated distribution		In-hospital death (Na = 44,200)
		N	%	Case-fatality (%)	CIb	P-valuec
Overall	153,124	773,273	100	5.7	5.5-5.9
Age						P<0.001
18-49	32,448	163,007	21.1	2.7	2.5-3.0
50-79	87,401	441,227	57.1	6.0	5.7-6.2
≥80	33,275	169,039	21.9	7.9	7.5-8.3
Sex						P<0.001
Male	73,324	369,954	47.9	6.0	5.8-6.3
Female	79,800	403,319	52.1	5.4	5.2-5.7
Race/ethnicityd						P<0.001
White	93,654	473,796	61.3	5.6	5.4-5.9
Black	20,814	105,294	13.6	5.8	5.4-6.2
Hispanic	9,074	45,842	5.9	6.1	5.6-6.8
Asian or other race/ethnicity	6,289	32,321	4.2	7.8	7.0-8.6
Not stated	23,293	116,020	15.0	5.3	4.7-6.0
Days of hospital stay						P<0.001
< 7 days	83,673	422,955	54.7	4.3	4.1-4.5
≥ 7 days	69,451	350,318	45.3	7.5	7.2-7.8
Primary expected payer						P<0.001
Medicare	85,207	431,696	55.8	6.7	6.4-6.9
Medicaid	13,829	69,660	9.0	4.8	4.4-5.2
Private including HMO	42,151	212,229	27.4	4.5	4.2-4.8
Self-pay or other payers	11,937	59,688	7.7	4.4	4.0-4.9
Operating room procedure						P<0.001
No procedure of any kind recorded	61,111	309,521	40.0	1.9	1.8-2.1
Non-operating room procedurerecordede	48,877	246,454	31.9	9.5	9.1-9.9
Operating room procedure recordedf	43,136	217,298	28.1	6.6	6.3-6.9
Number of comorbiditiesg						P<0.001
0	10,998	55,743	7.2	1.7	1.4-2.0
1	23,177	117,449	15.2	3.4	3.1-3.7
2	30,808	156,034	20.2	4.4	4.1-4.8
3	30,831	154,254	19.9	5.3	5.5-5.7
4	24,205	122,067	15.8	6.4	6.0-6.8
≥5	33,405	167,726	21.7	9.7	9.3-10.2

a. Estimated (N) number of in-hospital deaths with a diagnosis of VTE. b. 95% confidence interval. c. P-value for Pearson Chi-Square test. d. May not be nationally representative because not all participating states collect race/ethnicity information. e. Had at least one minor diagnostic or minor therapeutic procedure (without any major diagnostic or major therapeutic procedure) during hospitalization. f. Had at least one major diagnostic or major therapeutic procedure during hospitalization. g. Based on AHRQ 29-comorbidity index.

Of 29 comorbidities from the AHRQ comorbidity index, 12 comorbidities were significantly and positively associated with in-hospital death among hospitalizations with VTE, after adjustment of covariates including age, sex, race/ethnicity, days of hospital stay, primary expected payer, status of operating room procedure, and remaining comorbidities (Table 2). For example, when compared to subgroups without corresponding comorbidity, subgroups with comorbidity of “congestive heart failure,” “chronic pulmonary disease,” “coagulopathy,” “liver disease,” “lymphoma,” “fluid and electrolyte disorders,” “metastatic cancer,” “peripheral vascular disorders,” “pulmonary circulation disorders,” “renal failure,” “solid tumor without metastasis,” and “weight loss” were each independently associated with 1.07 to 2.06 times increased likelihoods of in-hospital death. The prevalence for having any one of 12 comorbidities ranged from 1.6% for “lymphoma” to 28.3% for “fluid and electrolyte disorders,” whereas the case-fatality rates fluctuated between 6.8% for “chronic pulmonary disease” and 13.6% for “coagulopathy” (Table 2). Furthermore, the increase in cumulative number of comorbidities generally corresponded to significantly elevated risks of in-hospital death among hospitalizations with VTE (P-trend<0.01) (Figure 2). The detection of a significant quadratic trend with an accompanying linear trend (P<0.001) signaled the presence of nonlinear variation (e.g., trend flattened out or leveled off) along with an overall linear trend (Figure 2). The disease category of “cardiovascular/blood/respiratory,” either by itself (21.8%) or combined with the disease categories for other comorbidities (27.6%) (i.e., “cancer,” “gastrointestinal/renal,” and “nutritional/body weight”), was most prevalent and accounted for nearly half (49.4%) of adult hospitalizations with VTE. The clustering patterns of 12 comorbidities by 4 disease categories were associated with 2.74 to 10.28 times increased likelihoods of in-hospital death, as compared to adult hospitalizations without any of the 12 comorbidities (Table 3). Regardless, 28.9% adult hospitalizations with VTE did not have any of the 12 comorbidities of concern.

Table 2

Prevalence of comorbidity, case-fatality rates and rate ratios for in-hospital death among adult hospitalizations with a diagnosis of VTE, NIS, 2009

AHRQ comorbidity indexa	Unweightedn=153,124b	EstimatedN	Prevalence of comorbidity		Association with in-hospital death
			%	95% CIc	Case-fatality rate	95% CI	Adjusted RRd	95% CI
Acquired immune deficiency syndrome	549	2,756	0.4	0.3-0.4	3.7	2.3-5.9	-e	-
Alcohol abuse	4,868	24,442	3.2	3.0-3.3	4.7	4.2-5.3	0.84	0.74-0.95
Anemia (deficiency)	38,261	192,405	24.9	23.9-25.8	5.9	5.6-6.3	0.72	0.68-0.76
Arthritis (rheumatoid)/collagen vascular diseases	5,209	26,254	3.4	3.3-3.5	4.9	4.4-5.6	-	-
Chronic blood loss anemia	2,904	14,636	1.9	1.8-2.0	5.6	4.8-6.6	0.66	0.57-0.77
Congestive heart failuref	19,627	99,176	12.8	12.4-13.3	10.8	10.3-11.4	1.43	1.36-1.50
Chronic pulmonary disease	32,301	163,376	21.1	20.5-21.7	6.8	6.4-7.2	1.07	1.02-1.12
Coagulopathy	12,685	63,524	8.2	7.8-8.6	13.6	12.8-14.4	1.84	1.74-1.94
Depression	15,878	80,027	10.3	10.0-10.7	3.6	3.3-4.0	0.72	0.67-0.79
Diabetes, uncomplicated	29,750	150,104	19.4	19.0-19.9	5.6	5.3-6.0	-	-
Diabetes with chronic complications	6,936	34,879	4.5	4.3-4.8	5.5	4.9-6.1	0.83	0.75-0.92
Drug abuse	3,806	19,116	2.5	2.3-2.7	3.3	2.8-4.0	0.80	0.67-0.95
Hypertension (uncomplicated and complicated)	82,484	416,519	53.9	53.0-54.7	5.0	4.7-5.2	0.70	0.66-0.73
Hypothyroidism	16,938	85,473	11.1	10.7-11.4	5.0	4.6-5.4	0.88	0.82-0.94
Liver disease	3,722	18,665	2.4	2.3-2.6	7.9	7.0-8.9	1.17	1.04-1.32
Lymphoma	2,512	12,719	1.6	1.5-1.8	9.4	8.3-10.7	1.43	1.27-1.62
Fluid and electrolyte disorders	43,505	218,526	28.3	27.4-29.1	10.8	10.4-11.2	1.90	1.82-1.98
Metastatic cancer	10,949	55,362	7.2	6.9-7.5	11.4	10.7-12.1	1.89	1.77-2.01
Other neurological disorders	14,270	72,079	9.3	9.1-9.6	6.2	5.8-6.7	-	-
Obesity	18,744	94,178	12.2	11.7-12.7	3.8	3.5-4.1	0.86	0.79-0.93
Paralysis	6,356	31,978	4.1	3.9-4.4	6.9	6.2-7.6	1.10	1.00-1.21
Peripheral vascular disorders	9,322	46,873	6.1	5.8-6.3	8.3	7.7-8.9	1.21	1.13-1.30
Psychoses	6,390	32,150	4.2	4.0-4.4	4.1	3.6-4.7	0.79	0.70-0.90
Pulmonary circulation disorders	30,267	152,273	19.7	19.2-20.2	11.0	10.5-11.5	2.06	1.97-2.16
Renal failure	23,036	116,090	15.0	14.5-15.6	8.2	7.8-8.7	1.38	1.30-1.45
Solid tumor without metastasis	7,487	37,893	4.9	4.7-5.1	7.6	6.9-8.2	1.34	1.23-1.47
Peptic ulcer disease excluding bleeding	73	371	0	0-0.1	-	-	-	-
Valvular disease	6,804	34,318	4.4	4.2-4.7	7.5	6.8-8.3	0.86	0.79-0.94
Weight loss	14,080	70,584	9.1	8.6-9.7	13.1	12.4-13.8	1.39	1.32-1.47

a. Referent groups were adult hospitalizations without corresponding comorbidity (suppressed). b. Subgroup with comorbidity are shown (subgroups without comorbidity: n = 153,124 - n for subgroup with corresponding comorbidity). c. 95% confidence interval. d. Rate ratios from log-linear regression model with backward elimination procedure that adjusted for age (continuous), sex, race/ethnicity, days of hospital stay (continuous), primary expected payer, major operating room procedure, and all comorbidities excluding “acquired immune deficiency syndrome,” “arthritis (rheumatoid)/collagen vascular diseases,” “diabetes uncomplicated,” “Other neurological disorders,” and “peptic ulcer disease excluding bleeding.” e. Variable not in the final regression model. f. Comorbidities significantly and positively associated with in-hospital death are bolded.

Figure 2

Adjusted rate ratios for in-hospital death by number of comorbidities among US adult hospitalizations with VTE, NIS, 2009

Table 3

Distribution of clustering patterns for 12 comorbidities by disease category and rate ratios for in-hospital death among adult hospitalizations with a diagnosis of VTE, NIS, 2009

Total # of categories	Cancera	Cardiovascular/Blood/Respiratoryb	Gastrointestinal/Renalc	Nutritional/Bodyweightd	Unweightedn	Estimated distribution		In-hospital death
	Clustering pattern					N	%	aRRe	CI
4	+f	+	+	+	740	3,730	0.5	10.28	8.66-12.20
3	+	+	+	-g	667	3,380	0.4	6.38	4.97-8.19
3	-	+	+	+	6,441	32,299	4.2	7.85	7.00-8.79
3	+	-	+	+	453	2,282	0.3	6.86	5.40-8.72
3	+	+	-	+	3,795	19,138	2.5	8.45	7.51-9.50
2	+	+	-	-	5,201	26,313	3.4	5.00	4.42-5.67
2	-	+	+	-	7,344	37,045	4.8	3.73	3.29-4.24
2	-	-	+	+	3,707	18,677	2.4	4.41	3.81-5.11
2	+	-	+	-	652	3,302	0.4	3.12	2.23-4.38
2	+	-	-	+	3,091	15,626	2.0	5.44	4.71-6.27
2	-	+	-	+	17,815	89,284	11.5	6.10	5.48-6.80
1	+	-	-	-	6,203	31,452	4.1	2.46	2.11-2.86
1	-	+	-	-	33,267	168,271	21.8	2.74	2.48-3.03
1	-	-	+	-	6,032	30,422	3.9	1.65	1.35-2.01
1	-	-	-	+	13,715	68,954	8.9	2.98	2.66-3.34
0	-	-	-	-	44,001	223,098	28.9	1.00	Referenceh
Total number of hospitalizations					153,124	773,273	100.0	-	-

a. Presence of one or more comorbidities of lymphoma, metastatic cancer, and solid tumor without metastasis. b. Presence of one or more comorbidities of congestive heart failure, chronic pulmonary disease, coagulopathy, peripheral vascular disorders, and pulmonary circulation disorders. c. Presence of one or more comorbidities of liver disease and renal failure. d. Presence of one or more comorbidities of fluid and electrolyte disorders and weight loss. e. Rate ratios from log-linear regression model that adjusted for age, sex, race/ethnicity, days of hospital stay, primary expected payer, major operating room procedure, and comorbidities retained without 12 comorbidities. f. Presence of one or more comorbidities of the disease category. g. Absence of any comorbidity of the disease category. h. Absence of 12 comorbidities.

Discussion

By using a large nationally representative sample, our study evaluated the AHRQ 29-comorbidity index encompassing the clustering patterns and associations with in-hospital death among US adult hospitalizations with a diagnosis of VTE that have not been reported in the past. Of US adult hospitalizations with VTE, about 9 in 10 had at least 1 comorbidity and 1 in 3 had at least 4 comorbidities. A vast majority of in-hospital deaths with VTE had at least 1 comorbidity. From the well-recognized “metastatic cancer (aRR=1.89; CI: 1.77-2.01)” to the less pronounced “fluid and electrolyte disorders (aRR=1.90; CI: 1.82-1.98),” we identified 12 of these 29 comorbidities that were significantly associated with the risk of in-hospital deaths. In addition, increases in the cumulative number of comorbidities were associated with significantly elevated risks of in-hospital death among those hospitalizations.

The findings of our study have several important implications for clinical and public health research, practice, and planning. First, the ubiquitous presence of co-morbidities among patients with VTE suggests that, to a great extent, VTE is an important marker or reminder for the co-existence of other diseases or conditions. For instance, VTE may reflect the presence of a biologically more aggressive cancer in an early stage 14. Therefore, healthcare practitioners must remain vigilant in evaluating patients with VTE, particularly those who may have clustering comorbidities that may predispose them to a heightened risk for death. Second, the breadth of co-morbidities among hospitalizations of patients with VTE demonstrates the complexity of potential disease-interacting mechanisms of (a) direct causation (e.g., cancer may compress adjacent veins to limit blood flow and produce procoagulant proteins and inflammatory cytokines that contribute to hypercoagulability) 36, 37, (b) associated risk factors (e.g., VTE and congestive heart failure may co-occur because inflammation and coronary heart disease are correlated risk factors, respectively) 38-40, (c) heterogeneity (e.g., aging and trauma are independent risk factors for either VTE or fluid and electrolyte disorders) 41, 42, and (d) independence (e.g., concurrent weight loss and renal failure resulting from cancer) 43. As such, comorbidities not only have value in diagnostic and prognostic assessment of patients with VTE 11, 44, 45, but can also affect quality of patient care (e.g., adherence to clinical guidelines) 46, 47. Third, we observed that almost half (49.4%) of adult hospitalizations with VTE also had at least one comorbidity in the “cardiovascular/blood/respiratory” disease category. Research suggests that concordant comorbidities are those diseases that may share overlapping pathophysiologic risk factors, thus benefit from similar disease management strategies and may result in improved quality of patient care 48, 49. For example, arterial thrombosis and VTE are two distinct forms of thrombosis with interrelated risk factors 50. The JUPITER study reported that the use of statins resulted in a 43% reduction of VTE events in apparently healthy adults aged 50 years and older with high levels of C-reactive protein (≥2mg/L) and normal levels of low-density lipoprotein cholesterol 51. In contrast, discordant comorbidities are not directly related in either pathogenesis or management of relevant diseases. Because of the additional implementation burden from multiple clinical recommendations or practice guidelines, competing demands for physician attention, and elevated risks of adverse drug events or complications, discordant comorbidities may lead to reduced quality of patient care 48, 49. Hence, substantial work remains for practitioners and researchers to elucidate the role of interacting VTE and comorbidities, to prioritize care of complex patients, and to inform prevention programs.

Based on the ascertainment of up to 25 diagnostic codes for each hospitalization in the NIS sample, a total of 44,200 in-hospital deaths were approximated among adult hospitalizations with VTE in 2009. Similar to the findings of our study, the 12 comorbidities overlapped with some comorbidities that were previously found to be associated with increased risks for in-hospital death in studies using a non-VTE-specific overall sample 31, 52. Possibly as a surrogate for relatively “healthy” patients when compared to those with more serious diseases, the presence of the 11 non-life-threatening comorbidities in our study was associated with decreased risks of in-hospital death (Table 2). Although the reason remained unclear for the lower case-fatality rate in hospitalization with “operating room procedure” than that of “non-operating room procedure,” additional research discerning these risk factors is needed in order to identify potential diagnostic and therapeutic procedures (e.g., venous catheterization) and associated conditions that may contribute to an elevated risk of death.

Our study has several limitations. We were unable to determine any causal inference because the cross-sectional study design cannot establish such a relationship. Due to the constraints of administrative datasets, we were unable to control for potential medications that may otherwise affect short-term mortality in patients with VTE. Even though ICD-9 codes provide a uniform identification of comorbidities in administrative datasets, the accuracy of diagnostic codes may vary by physician documentations, code assignments, usage patterns for diagnostic tests, changes of codes over time, and institutional reimbursement policies 53.

More than 66% of all healthcare costs or 96% of Medicare expenditures are for individuals with two or more chronic diseases and conditions 54, 55. Also, given that comorbidities are highly prevalent among aging US adults and are associated with worse health outcomes and more complex clinical management, effectively addressing multiple chronic diseases and conditions poses a complex set of challenges for clinicians, patients, and healthcare systems 54-56. More results from intervention studies that can demonstrate efficacy and safety in the presence of co-occurring diseases are beneficial.

Conclusion

The presence of multiple comorbidities is ubiquitous among hospitalizations of adults with VTE and among in-hospital deaths with VTE in the United States. The findings of our study further suggest that, among hospitalizations of adults with VTE, the presence of certain comorbidities or clustering of these comorbidities significantly elevates the risk of in-hospital death.