Literature DB >> 23983336

Anti-diabetic activities of the methanol leaf extracts of Hymenocardia acida (tul.) in alloxan-induced diabetic rats.

Ihechiluru I Ezeigbo1, Isaac U Asuzu.   

Abstract

The effect of methanolic extract of Hymenocardia acida leaves on diabetes and associated lipidemia were investigated on experimentally-induced diabetic rats. The extract did not demonstrate any acutely toxic effect in rats within the dose range (250 mg/kg - 2000 mg/kg) employed in the study; hence it was well tolerated by the rats. In all experiments, the anti-diabetic effects were dose-dependent and comparable to that of glibenclamide (2 mg/kg) standard. At a dose of 500 mg/kg, lipid profile markers such as the serum total cholesterol (TC) levels, LDL-C, triglycerides and HDL-C were significantly lower (p <0.05) than those of both the treated and untreated controls.

Entities:  

Keywords:  Alloxan monohydrate; Diabetes mellitus; Glibenclamide; Hymenocardia acida; Lipid profile

Mesh：

Substances：

Year:  2011        PMID： 23983336      PMCID： PMC3746633          DOI： 10.4314/ajtcam.v9i2.4

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  15 in total

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  1 in total

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Journal:  Afr J Tradit Complement Altern Med       Date:  2016-07-03
  1 in total

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