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Literature DB >> 23983019

Biochemical and physical signal gradients in hydrogels to control stem cell behavior.

Oju Jeon¹, Daniel S Alt, Stephen W Linderman, Eben Alsberg.

Abstract

Three-dimensional (3D) gradients of biochemical and physical signals in macroscale degradable hydrogels are engineered that can regulate photoencapsulated human mesenchymal stem cell (hMSC) behavior. This simple, cytocompatible, and versatile gradient system may be a valuable tool for researchers in biomaterials science to control stem cell fate in 3D and guide tissue regeneration.

Entities: CellLine Chemical Disease Gene Species

Keywords: alginate; biomaterials; gradients; hydrogels; stem cells; tissue engineering

Mesh：

Substances：

Year: 2013 PMID： 23983019 PMCID： PMC3863582 DOI： 10.1002/adma.201302364

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

66 in total

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6. Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels.

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9. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate.

Authors: Nathaniel Huebsch; Praveen R Arany; Angelo S Mao; Dmitry Shvartsman; Omar A Ali; Sidi A Bencherif; José Rivera-Feliciano; David J Mooney
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10. Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs.

Authors: Leo Q Wan; Jie Jiang; Diana E Arnold; X Edward Guo; Helen H Lu; Van C Mow
Journal: Cell Mol Bioeng Date: 2008-03-01 Impact factor: 2.321

26 in total

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3. Modulating physical, chemical, and biological properties in 3D printing for tissue engineering applications.

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4. Converting 2D Nanofiber Membranes to 3D Hierarchical Assemblies with Structural and Compositional Gradients Regulates Cell Behavior.

Authors: Shixuan Chen; Alec McCarthy; Johnson V John; Yajuan Su; Jingwei Xie
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Review 5. Spatial regulation of controlled bioactive factor delivery for bone tissue engineering.

Authors: Julia E Samorezov; Eben Alsberg
Journal: Adv Drug Deliv Rev Date: 2014-11-29 Impact factor: 15.470

6. Spatial control of cell gene expression by siRNA gradients in biodegradable hydrogels.

Authors: Michael C Hill; Minh K Nguyen; Oju Jeon; Eben Alsberg
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Authors: J Kent Leach; Jacklyn Whitehead
Journal: ACS Biomater Sci Eng Date: 2017-03-14

8. Microgels produced using microfluidic on-chip polymer blending for controlled released of VEGF encoding lentivectors.

Authors: Justin L Madrigal; Shonit N Sharma; Kevin T Campbell; Roberta S Stilhano; Rik Gijsbers; Eduardo A Silva
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9. Dual-crosslinked hydrogel microwell system for formation and culture of multicellular human adipose tissue-derived stem cell spheroids.

Authors: Oju Jeon; Robyn Marks; David Wolfson; Eben Alsberg
Journal: J Mater Chem B Date: 2016-04-18 Impact factor: 6.331

10. Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine.

Authors: Minh Khanh Nguyen; Eben Alsberg
Journal: Prog Polym Sci Date: 2014-07 Impact factor: 29.190