OBJECTIVE: To evaluate associations between severity of knee osteoarthritis (OA) on magnetic resonance imaging (MRI) and treatment outcomes in knee OA patients treated withexercise therapy in an exploratory study. METHODS:Ninety-five participants with knee OA in a 12-weekexercise program had obtained 3.0T MRI scans of the knee joint prior to treatment. MRI data were systematically assessed for OA severity of multiple features (cartilage integrity, bone marrow lesions, osteophyte formation, effusion/synovitis, and meniscal abnormalities) according to the Boston Leeds Osteoarthritis Knee Score method. Regression analyses were performed to analyze associations between OA severity on MRI (for the tibiofemoral and patellofemoral [PF] compartments) and outcome of exercise therapy, i.e., changes in activity limitations (Western Ontario and McMaster Universities Osteoarthritis Index physical function; primary outcome), pain and upper leg muscle strength, and treatment response (Outcome Measures in Rheumatology/Osteoarthritis Research Society International criteria). RESULTS: Improvements of 24%, 34%, and 21% on average in activity limitations, pain, and muscle strength, respectively, after 12-week exercise therapy were found (P < 0.001). Severity of abnormalities in PF cartilage integrity was significantly associated with fewer improvements in both activity limitations (P = 0.01) and muscle strength (P = 0.04). Severity of PF osteophyte formation was significantly associated with fewer improvements in muscle strength (P < 0.01). All other features on MRI were not associated with treatment outcome. CONCLUSION: Effectiveness of exercise therapy seems to be independent of OA severity on MRI, except for abnormalities in cartilage integrity and osteophyte formation, both in the PF compartment. Our study suggests that all grades of OA severity on MRI can benefit from professionally supervised exercise therapy, although the effects might be reduced in patients with advanced PF OA.
RCT Entities:
OBJECTIVE: To evaluate associations between severity of knee osteoarthritis (OA) on magnetic resonance imaging (MRI) and treatment outcomes in knee OA patients treated with exercise therapy in an exploratory study. METHODS: Ninety-five participants with knee OA in a 12-week exercise program had obtained 3.0T MRI scans of the knee joint prior to treatment. MRI data were systematically assessed for OA severity of multiple features (cartilage integrity, bone marrow lesions, osteophyte formation, effusion/synovitis, and meniscal abnormalities) according to the Boston Leeds Osteoarthritis Knee Score method. Regression analyses were performed to analyze associations between OA severity on MRI (for the tibiofemoral and patellofemoral [PF] compartments) and outcome of exercise therapy, i.e., changes in activity limitations (Western Ontario and McMaster Universities Osteoarthritis Index physical function; primary outcome), pain and upper leg muscle strength, and treatment response (Outcome Measures in Rheumatology/Osteoarthritis Research Society International criteria). RESULTS: Improvements of 24%, 34%, and 21% on average in activity limitations, pain, and muscle strength, respectively, after 12-week exercise therapy were found (P < 0.001). Severity of abnormalities in PF cartilage integrity was significantly associated with fewer improvements in both activity limitations (P = 0.01) and muscle strength (P = 0.04). Severity of PF osteophyte formation was significantly associated with fewer improvements in muscle strength (P < 0.01). All other features on MRI were not associated with treatment outcome. CONCLUSION: Effectiveness of exercise therapy seems to be independent of OA severity on MRI, except for abnormalities in cartilage integrity and osteophyte formation, both in the PF compartment. Our study suggests that all grades of OA severity on MRI can benefit from professionally supervised exercise therapy, although the effects might be reduced in patients with advanced PF OA.
Authors: Franz Kainberger; Anna L Falkowski; Lena Hirtler; Georg Riegler; Thomas Schlegl; Siddharth Thaker; Janina Patsch; Richard Crevenna Journal: Wien Med Wochenschr Date: 2016-01-27
Authors: Cynthia J Coffman; Liubov Arbeeva; Todd A Schwartz; Leigh F Callahan; Yvonne M Golightly; Adam P Goode; Kim M Huffman; Kelli D Allen Journal: Arthritis Care Res (Hoboken) Date: 2022-05-02 Impact factor: 5.178
Authors: Melanie A Holden; Danielle L Burke; Jos Runhaar; Danielle van Der Windt; Richard D Riley; Krysia Dziedzic; Amardeep Legha; Amy L Evans; J Haxby Abbott; Kristin Baker; Jenny Brown; Kim L Bennell; Daniël Bossen; Lucie Brosseau; Kanda Chaipinyo; Robin Christensen; Tom Cochrane; Mariette de Rooij; Michael Doherty; Helen P French; Sheila Hickson; Rana S Hinman; Marijke Hopman-Rock; Michael V Hurley; Carol Ingram; Jesper Knoop; Inga Krauss; Chris McCarthy; Stephen P Messier; Donald L Patrick; Nilay Sahin; Laura A Talbot; Robert Taylor; Carolien H Teirlinck; Marienke van Middelkoop; Christine Walker; Nadine E Foster Journal: BMJ Open Date: 2017-12-22 Impact factor: 2.692
Authors: Kelli D Allen; Dennis Bongiorni; Kevin Caves; Cynthia J Coffman; Theresa A Floegel; Heather M Greysen; Katherine S Hall; Bryan Heiderscheit; Helen M Hoenig; Kim M Huffman; Miriam C Morey; Shalini Ramasunder; Herbert Severson; Battista Smith; Courtney Van Houtven; Sandra Woolson Journal: BMC Musculoskelet Disord Date: 2019-05-28 Impact factor: 2.362