| Literature DB >> 23982701 |
Wei Zhang1, Hong Chan, Louwei Wei, Zhongmian Pan, Jieqing Zhang, Li Li.
Abstract
It has been reported that heparanase (HPSE) is overexpressed in ovarian cancer and is associated with tumor invasion and metastasis. However, a systematic study on the contribution of HPSE to tumor metastasis is rarely reported. In this study, based on the measurement of HPSE serum concentration, the expression of HPSE at both the mRNA and protein levels in tumors and its effects on the biological behaviors of cancer cells, we elucidated the role of HPSE in tumor invasion and metastasis in ovarian cancer and concluded that either the expression of HPSE in cancer and/or the serum concentration of HPSE may be a useful biomarker for the evaluation of surgery effects and prognosis prediction.Entities:
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Year: 2013 PMID： 23982701 DOI： 10.3892/or.2013.2701
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906