PURPOSE: To identify the impact of the histological diagnosis on the prognosis of prenatally diagnosed sacrococcygeal teratoma (SCT), we analyzed the data obtained during prenatal surveillance and assessed the postnatal outcomes in a large cohort of fetuses with SCT in Japan. METHODS: A nationwide retrospective cohort study was conducted among 97 fetuses prenatally diagnosed with SCT between 2000 and 2009. Of these, 84 had a histological diagnosis. In addition, we conducted a second surveillance program of the prognosis of 72 patients who were reported to be alive at the initial surveillance conducted 2 years previously. RESULTS: The tumors comprised 51 (61 %) mature teratomas, 33 (39 %) immature teratomas and 0 (0 %) malignant teratomas. Immature teratomas were also associated with a significantly higher mortality rate (immature teratomas: 8/31, mature teratomas: 2/48). Late recurrence was observed in six of 72 cases (8.3 %). Among these six cases, recurrence with a malignant component was observed in four patients. All six patients were successfully treated. CONCLUSIONS: Mature teratoma was the most common histological type observed in this study. The patients with immature teratomas exhibited an increased risk of mortality. Late recurrence was observed in 8.3 % of the cases.
PURPOSE: To identify the impact of the histological diagnosis on the prognosis of prenatally diagnosed sacrococcygeal teratoma (SCT), we analyzed the data obtained during prenatal surveillance and assessed the postnatal outcomes in a large cohort of fetuses with SCT in Japan. METHODS: A nationwide retrospective cohort study was conducted among 97 fetuses prenatally diagnosed with SCT between 2000 and 2009. Of these, 84 had a histological diagnosis. In addition, we conducted a second surveillance program of the prognosis of 72 patients who were reported to be alive at the initial surveillance conducted 2 years previously. RESULTS: The tumors comprised 51 (61 %) mature teratomas, 33 (39 %) immature teratomas and 0 (0 %) malignant teratomas. Immature teratomas were also associated with a significantly higher mortality rate (immature teratomas: 8/31, mature teratomas: 2/48). Late recurrence was observed in six of 72 cases (8.3 %). Among these six cases, recurrence with a malignant component was observed in four patients. All six patients were successfully treated. CONCLUSIONS:Mature teratoma was the most common histological type observed in this study. The patients with immature teratomas exhibited an increased risk of mortality. Late recurrence was observed in 8.3 % of the cases.
Authors: Antoine De Backer; Gerard C Madern; Friederike G A J Hakvoort-Cammel; Patrick Haentjens; J Wolter Oosterhuis; Frans W J Hazebroek Journal: J Pediatr Surg Date: 2006-01 Impact factor: 2.545
Authors: S N Huddart; J R Mann; K Robinson; F Raafat; J Imeson; P Gornall; M Sokal; E Gray; P McKeever; A Oakhill Journal: Pediatr Surg Int Date: 2002-12-19 Impact factor: 1.827
Authors: Jillian R Mann; Elizabeth S Gray; Claire Thornton; Faro Raafat; Kathleen Robinson; Gary S Collins; Peter Gornall; Simon N Huddart; Juliet P Hale; Anthony Oakhill Journal: J Clin Oncol Date: 2008-06-09 Impact factor: 44.544
Authors: Lieke J van Heurn; Audrey B C Coumans; Joep P M Derikx; Mireille N Bekker; Katia M Bilardo; Leonie K Duin; Maarten F C M Knapen; Eva Pajkrt; Esther Sikkel; L W Ernest van Heurn; Dick Oepkes Journal: Prenat Diagn Date: 2021-08-05 Impact factor: 3.242