OBJECTIVES: To evaluate the association of pain and pruritus with Dermatologic Quality of Life (QoL) and cutaneous disease activity in patients with 1) specific cutaneous lupus erythematosus (CLE) lesions, 2) non-specific CLE lesions and 3) both types of CLE lesions. METHODS: We evaluated 42 consecutive SLE patients with at least one active lesion attributed to lupus. Pain and pruritus were evaluated using a visual analogue scale, dermatologic QoL with the DLQI, clinical activity with the CLASI score and systemic activity with the SLEDAI-2K. RESULTS: The patients were predominantly females, mean age 34.2±11.2 years and median SLE duration of 7 years. Sixteen patients (38%) had specific lesions, 12 (28.5%) non-specific lesions and 14 patients (33%) both lesions. Patients with both lesions had the highest CLASI activity scores (median 17) (p<0.0001), all the cases of severe activity (p=0.002) and higher (worst) DLQI scores (median 11.5, p=0.04). The overall median pain score was 5 (0-9). Patients with non-specific or the combination of both CLE lesions had more pain (p<0.008). Pain correlated with the DLQI (τ=0.38, p=0.001) and the CLASI activity score (τ=0.47, p=0.002). Pain was more intense in vasculitis and bullous lesions followed by oral ulcers. Pruritus score did not differ among groups (median 6) and did not correlate with the DLQI or the CLASI activity score. CONCLUSIONS: We identified pain as a factor that correlated with dermatologic QoL and cutaneous activity. In this sense, this feature needs to be considered as part of the treatment targets in lupus.
OBJECTIVES: To evaluate the association of pain and pruritus with Dermatologic Quality of Life (QoL) and cutaneous disease activity in patients with 1) specific cutaneous lupus erythematosus (CLE) lesions, 2) non-specific CLE lesions and 3) both types of CLE lesions. METHODS: We evaluated 42 consecutive SLEpatients with at least one active lesion attributed to lupus. Pain and pruritus were evaluated using a visual analogue scale, dermatologic QoL with the DLQI, clinical activity with the CLASI score and systemic activity with the SLEDAI-2K. RESULTS: The patients were predominantly females, mean age 34.2±11.2 years and median SLE duration of 7 years. Sixteen patients (38%) had specific lesions, 12 (28.5%) non-specific lesions and 14 patients (33%) both lesions. Patients with both lesions had the highest CLASI activity scores (median 17) (p<0.0001), all the cases of severe activity (p=0.002) and higher (worst) DLQI scores (median 11.5, p=0.04). The overall median pain score was 5 (0-9). Patients with non-specific or the combination of both CLE lesions had more pain (p<0.008). Pain correlated with the DLQI (τ=0.38, p=0.001) and the CLASI activity score (τ=0.47, p=0.002). Pain was more intense in vasculitis and bullous lesions followed by oral ulcers. Pruritus score did not differ among groups (median 6) and did not correlate with the DLQI or the CLASI activity score. CONCLUSIONS: We identified pain as a factor that correlated with dermatologic QoL and cutaneous activity. In this sense, this feature needs to be considered as part of the treatment targets in lupus.
Authors: Ashwaq AlE'ed; Pinar Ozge Avar Aydin; Nora Al Mutairi; Alhanouf AlSaleem; Hafize Emine Sonmez; Michael Henrickson; Jennifer L Huggins; Seza Ozen; Sulaiman M Al-Mayouf; Hermine I Brunner Journal: Lupus Sci Med Date: 2018-11-17
Authors: Jaewon Lee; Jin Lim; Jong Seo Park; Miso Kim; Tae-Yong Kim; Tae Min Kim; Kyung-Hun Lee; Bhumsuk Keam; Sae-Won Han; Je-Ho Mun; Kwang Hyun Cho; Seong Jin Jo Journal: Cancer Res Treat Date: 2017-12-14 Impact factor: 4.679
Authors: Dominik Samotij; Justyna Szczęch; Carolyn J Kushner; Mohammad Rafiqul Mowla; Aleksandra Dańczak-Pazdrowska; Emiliano Antiga; François Chasset; Fukumi Furukawa; Minoru Hasegawa; Hideo Hashizume; Aminul Islam; Takaharu Ikeda; Aleksandra Lesiak; Adriana Polańska; Laurent Misery; Jacek C Szepietowski; Daisuke Tsuruta; Zygmunt Adamski; Victoria P Werth; Adam Reich Journal: Biomed Res Int Date: 2018-07-25 Impact factor: 3.411