Brent A Williams1, Michael E Merhige. 1. Geisinger Health System, Geisinger Center for Health Research, 100 North Academy Avenue, Danville, PA 17822, USA. Electronic address: bawilliams2@geisinger.edu.
Abstract
OBJECTIVE: To determine whether an elevated neutrophil-lymphocyte ratio (NLR) is associated with chronically impaired myocardial perfusion in patients with known or suspected coronary disease. BACKGROUND: Elevated NLRs are positively associated with cardiac events, anatomic coronary disease, and myocardial infarct size. However, no study has evaluated the association between NLR and chronically impaired myocardial perfusion. METHODS: This study included 683 patients undergoing cardiac positron emission tomography (PET) with a calculable NLR within 90 days of PET. The primary outcome was myocardial perfusion defect size measured in percent of left ventricular mass (%LV60). RESULTS: NLR was independently associated with %LV60 when analyzed as both a continuous and binary outcome (p < 0.001). Individuals with NLR above the 90th percentile had a 5-fold increased likelihood of significant perfusion defects compared to individuals with NLR between the 10th and 25th percentiles (Odds ratio = 4.7, p < 0.001). CONCLUSION: An elevated NLR demonstrated strong associations with myocardial perfusion.
OBJECTIVE: To determine whether an elevated neutrophil-lymphocyte ratio (NLR) is associated with chronically impaired myocardial perfusion in patients with known or suspected coronary disease. BACKGROUND: Elevated NLRs are positively associated with cardiac events, anatomic coronary disease, and myocardial infarct size. However, no study has evaluated the association between NLR and chronically impaired myocardial perfusion. METHODS: This study included 683 patients undergoing cardiac positron emission tomography (PET) with a calculable NLR within 90 days of PET. The primary outcome was myocardial perfusion defect size measured in percent of left ventricular mass (%LV60). RESULTS: NLR was independently associated with %LV60 when analyzed as both a continuous and binary outcome (p < 0.001). Individuals with NLR above the 90th percentile had a 5-fold increased likelihood of significant perfusion defects compared to individuals with NLR between the 10th and 25th percentiles (Odds ratio = 4.7, p < 0.001). CONCLUSION: An elevated NLR demonstrated strong associations with myocardial perfusion.
Authors: Nicholas G Kounis; George D Soufras; Grigorios Tsigkas; George Hahalis Journal: Int J Cardiovasc Imaging Date: 2014-01-03 Impact factor: 2.357
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