Literature DB >> 23981028

Mediator lipidomics in ophthalmology: targets for modulation in inflammation, neuroprotection and nerve regeneration.

William C Gordon1, Nicolas G Bazan.   

Abstract

Studies in the central nervous system (CNS) and retina have revealed the significance of docosahexaenoic acid (DHA), an essential omega-3, 22 carbon 6 double bond (22:6), fatty acid. DHA is necessary for various functions in the CNS, including neuronal membrane bio- and synaptogenesis in memory and vision, and it is the precursor for docosanoids and neuroprotectin D1 (NPD1; 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z hexaenoic acid), a DHA bio-derivative with neuroprotective properties. This review covers three targets in ophthalmology for mediator lipidomics, a subgroup within the field of metabolomics: inflammation, neuroprotection and nerve regeneration. It also discusses the role DHA, NPD1 and other lipid mediators play in these three areas.

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Year:  2013        PMID： 23981028     DOI： 10.3109/02713683.2013.827211

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  19 in total

1.  Role of the non-enzymatic metabolite of eicosapentaenoic acid, 5-epi-5-F3t-isoprostane in the regulation of [ (3)H]D-aspartate release in isolated bovine retina.

Authors:  Jamal Jamil; Pratik Bankhele; Ankita Salvi; Jaimee E Mannix; Camille Oger; Alexandre Guy; Jean-Marie Galano; Thierry Durand; Ya Fatou Njie-Mbye; Sunny E Ohia; Catherine A Opere
Journal:  Neurochem Res       Date:  2014-09-25       Impact factor: 3.996

2.  The membrane attack complex in aging human choriocapillaris: relationship to macular degeneration and choroidal thinning.

Authors:  Robert F Mullins; Desi P Schoo; Elliott H Sohn; Miles J Flamme-Wiese; Grefachew Workamelahu; Rebecca M Johnston; Kai Wang; Budd A Tucker; Edwin M Stone
Journal:  Am J Pathol       Date:  2014-09-07       Impact factor: 4.307

3.  Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes.

Authors:  Hanna Shevalye; Matthew S Yorek; Lawrence J Coppey; Amey Holmes; Matthew M Harper; Randy H Kardon; Mark A Yorek
Journal:  J Neurophysiol       Date:  2015-04-29       Impact factor: 2.714

4.  Enriching the diet with menhaden oil improves peripheral neuropathy in streptozotocin-induced type 1 diabetic rats.

Authors:  Lawrence J Coppey; Eric P Davidson; Alexander Obrosov; Mark A Yorek
Journal:  J Neurophysiol       Date:  2014-11-05       Impact factor: 2.714

Review 5.  Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy.

Authors:  S Scott Whitmore; Elliott H Sohn; Kathleen R Chirco; Arlene V Drack; Edwin M Stone; Budd A Tucker; Robert F Mullins
Journal:  Prog Retin Eye Res       Date:  2014-12-05       Impact factor: 21.198

Review 6.  Lipidomics: Techniques, Applications, and Outcomes Related to Biomedical Sciences.

Authors:  Kui Yang; Xianlin Han
Journal:  Trends Biochem Sci       Date:  2016-09-20       Impact factor: 13.807

Review 7.  The Potential Role of Fatty Acids in Treating Diabetic Neuropathy.

Authors:  Mark A Yorek
Journal:  Curr Diab Rep       Date:  2018-08-25       Impact factor: 4.810

8.  Astrocyte-derived lipoxins A4 and B4 promote neuroprotection from acute and chronic injury.

Authors:  Izhar Livne-Bar; Jessica Wei; Hsin-Hua Liu; Samih Alqawlaq; Gah-Jone Won; Alessandra Tuccitto; Karsten Gronert; John G Flanagan; Jeremy M Sivak
Journal:  J Clin Invest       Date:  2017-11-06       Impact factor: 14.808

Review 9.  Indirect traumatic optic neuropathy.

Authors:  Eric L Singman; Nitin Daphalapurkar; Helen White; Thao D Nguyen; Lijo Panghat; Jessica Chang; Timothy McCulley
Journal:  Mil Med Res       Date:  2016-01-11

Review 10.  Fair-Weather Friends: Evidence of Lipoxin Dysregulation in Neurodegeneration.

Authors:  Changmo Kim; Izhar Livne-Bar; Karsten Gronert; Jeremy M Sivak
Journal:  Mol Nutr Food Res       Date:  2020-01-07       Impact factor: 5.914
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