J Guo1, L Yu, J Zhang, N Chen, M Zhou, L He. 1. Department of Neurology, West China Hospital of Sichuan University, Chengdu, China.
Abstract
OBJECTIVES: Stroke is a major cause of long-term disability and morbidity worldwide. C-reactive protein (CRP), an inflammatory marker, has been reported to be an independent predictor of functional outcome after ischemic stroke (IS). Because several single nucleotide polymorphisms (SNPs) at the CRP locus have been linked with elevated CRP levels, we hypothesized that CRP genetic variation might be associated with functional disability in patients after first-ever IS. METHODS: A total of 1716 patients from western China with first-ever IS were genotyped for the CRP SNPs rs1130864 and rs1800947 using the ligation detection reaction method. Functional outcome was assessed 3 months after IS using the modified Rankin Scale. Then, we tested the association of CRP SNP genotypes with stroke outcome after adjusting for non-genetic factors. RESULTS: Our data showed a significant association between the T allele of rs1130864 and poor functional outcome in IS patients. In addition, the presence of TT+CT genotypes of rs1130864 strongly predicted functional disability within the first 3 months, even after adjusting for potential confounders. CONCLUSIONS: Our study indicates that SNP rs1130864 in the CRP gene is an independent predictor of 3-month functional outcome in patients with first-onset IS in a Han Chinese population. Further studies in different ethnic groups are needed to validate our findings.
OBJECTIVES:Stroke is a major cause of long-term disability and morbidity worldwide. C-reactive protein (CRP), an inflammatory marker, has been reported to be an independent predictor of functional outcome after ischemic stroke (IS). Because several single nucleotide polymorphisms (SNPs) at the CRP locus have been linked with elevated CRP levels, we hypothesized that CRP genetic variation might be associated with functional disability in patients after first-ever IS. METHODS: A total of 1716 patients from western China with first-ever IS were genotyped for the CRP SNPs rs1130864 and rs1800947 using the ligation detection reaction method. Functional outcome was assessed 3 months after IS using the modified Rankin Scale. Then, we tested the association of CRP SNP genotypes with stroke outcome after adjusting for non-genetic factors. RESULTS: Our data showed a significant association between the T allele of rs1130864 and poor functional outcome in IS patients. In addition, the presence of TT+CT genotypes of rs1130864 strongly predicted functional disability within the first 3 months, even after adjusting for potential confounders. CONCLUSIONS: Our study indicates that SNP rs1130864 in the CRP gene is an independent predictor of 3-month functional outcome in patients with first-onset IS in a Han Chinese population. Further studies in different ethnic groups are needed to validate our findings.
Authors: Laura Ibáñez; Pablo Sebastián Velli; Roser Font; Angeles Jaén; Josep Royo; Daniel Irigoyen; Mireia Cairó; Alejandro De la Sierra; María Jesús Arranz; David Gallardo; David Dalmau Journal: PLoS One Date: 2014-11-10 Impact factor: 3.240
Authors: He-Hong Geng; Xin-Wang Wang; Rong-Li Fu; Meng-Juan Jing; Ling-Ling Huang; Qing Zhang; Xiao-Xiao Wang; Pei-Xi Wang Journal: Int J Environ Res Public Health Date: 2016-06-27 Impact factor: 3.390