OBJECTIVE: To compare the efficacy and safety between anthracycline & taxane and anthracycline in the treatment of breast cancer. METHODS: Computer-assisted literature search was performed with PubMed, MEDLINE, EMBASE and Cochrane Controlled Trials Register (CCTR) to identify pertinent literatures. Software RevMan 5.0 was used for statistical analysis. The measurement of interest outcomes included severe neurotoxicity, death without breast cancer recurrences, leukemia, venous thrombus and severe cardiotoxicity. RESULTS: A total of 10 randomized controlled trial studies (RCTs) containing 18,198 cases were selected in this meta-analysis. Of which, 9,902 cases were treated with anthracycline & taxane and 8,296 cases treated with anthracycline alone as control. Anthracycline & taxane showed lower risks of incident leukemia (RR = 0.40; 95% CI: 0.18, 0.90), venous thrombus (RR = 0.49; 95% CI: 0.29, 0.84) and severe cardiotoxicity (RR = 0.41, 95%CI: 0.26, 0.66), but higher risks of incident severe neurotoxicity (RR = 5.97; 95% CI: 1.72, 20.65) and non-recurrent death (RR = 1.79; 95% CI: 1.06, 3.04), compared to anthracycline alone. CONCLUSION: Clinically important differences exist for general safety in favour of the anthracycline & taxane rather than anthracycline alone. However, as a result of tumor recurrent rate, anthracycline might be superior to anthracycline & taxane. A longer duration of follow-up and a larger number of cases are required to better assess the efficacy and safety profile of the treatment of breast cancer.
OBJECTIVE: To compare the efficacy and safety between anthracycline & taxane and anthracycline in the treatment of breast cancer. METHODS: Computer-assisted literature search was performed with PubMed, MEDLINE, EMBASE and Cochrane Controlled Trials Register (CCTR) to identify pertinent literatures. Software RevMan 5.0 was used for statistical analysis. The measurement of interest outcomes included severe neurotoxicity, death without breast cancer recurrences, leukemia, venous thrombus and severe cardiotoxicity. RESULTS: A total of 10 randomized controlled trial studies (RCTs) containing 18,198 cases were selected in this meta-analysis. Of which, 9,902 cases were treated with anthracycline & taxane and 8,296 cases treated with anthracycline alone as control. Anthracycline & taxane showed lower risks of incident leukemia (RR = 0.40; 95% CI: 0.18, 0.90), venous thrombus (RR = 0.49; 95% CI: 0.29, 0.84) and severe cardiotoxicity (RR = 0.41, 95%CI: 0.26, 0.66), but higher risks of incident severe neurotoxicity (RR = 5.97; 95% CI: 1.72, 20.65) and non-recurrent death (RR = 1.79; 95% CI: 1.06, 3.04), compared to anthracycline alone. CONCLUSION: Clinically important differences exist for general safety in favour of the anthracycline & taxane rather than anthracycline alone. However, as a result of tumor recurrent rate, anthracycline might be superior to anthracycline & taxane. A longer duration of follow-up and a larger number of cases are required to better assess the efficacy and safety profile of the treatment of breast cancer.
Authors: Henri Roché; Pierre Fumoleau; Marc Spielmann; Jean-Luc Canon; Thierry Delozier; Daniel Serin; Michel Symann; Pierre Kerbrat; Patrick Soulié; Françoise Eichler; Patrice Viens; Alain Monnier; Anita Vindevoghel; Mario Campone; Marie-Josèphe Goudier; Jacques Bonneterre; Jean-Marc Ferrero; Anne-Laure Martin; Jean Genève; Bernard Asselain Journal: J Clin Oncol Date: 2006-11-20 Impact factor: 44.544
Authors: Miguel Martín; Miguel A Seguí; Antonio Antón; Amparo Ruiz; Manuel Ramos; Encarna Adrover; Ignacio Aranda; Alvaro Rodríguez-Lescure; Regina Grosse; Lourdes Calvo; Agustí Barnadas; Dolores Isla; Purificación Martinez del Prado; Manuel Ruiz Borrego; Jerzy Zaluski; Angels Arcusa; Montserrat Muñoz; José M López Vega; José R Mel; Blanca Munarriz; Cristina Llorca; Carlos Jara; Emilio Alba; Jesús Florián; Junfang Li; José A López García-Asenjo; Amparo Sáez; María José Rios; Sergio Almenar; Gloria Peiró; Ana Lluch Journal: N Engl J Med Date: 2010-12-02 Impact factor: 91.245
Authors: Stephen E Jones; Michael A Savin; Frankie Ann Holmes; Joyce A O'Shaughnessy; Joanne L Blum; Svetislava Vukelja; Kristi J McIntyre; John E Pippen; James H Bordelon; Robert Kirby; John Sandbach; William J Hyman; Pankaj Khandelwal; Angel G Negron; Donald A Richards; Stephen P Anthony; Robert G Mennel; Kristi A Boehm; Walter G Meyer; Lina Asmar Journal: J Clin Oncol Date: 2006-12-01 Impact factor: 44.544
Authors: Lori J Goldstein; Anne O'Neill; Joseph A Sparano; Edith A Perez; Lawrence N Shulman; Silvana Martino; Nancy E Davidson Journal: J Clin Oncol Date: 2008-08-04 Impact factor: 44.544
Authors: Paul Ellis; Peter Barrett-Lee; Lindsay Johnson; David Cameron; Andrew Wardley; Susan O'Reilly; Mark Verrill; Ian Smith; John Yarnold; Robert Coleman; Helena Earl; Peter Canney; Chris Twelves; Christopher Poole; David Bloomfield; Penelope Hopwood; Stephen Johnston; Mitchell Dowsett; John M S Bartlett; Ian Ellis; Clare Peckitt; Emma Hall; Judith M Bliss Journal: Lancet Date: 2009-05-16 Impact factor: 79.321