| Literature DB >> 23978649 |
Lin Zhou1, Xuefeng Ge, Jihua Liu, Jiahong Zhou, Shaohua Wei, Fuyou Li, Jian Shen.
Abstract
Hypocrellin A (HA), an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex, which exhibits enhanced (1)O2 generation quantum yield through the increased intersystem crossing efficiency mediated by internal heavy atom effect. Besides, the chelate process greatly improved the water solubility of HA. Comparative studies with HA and complexes have demonstrated that the heavy-atom effect on HA molecules enhances the efficiency of in vitro photodynamic (PDT) efficacy.Entities:
Keywords: Anticancer activity; Complex; Hypocrellin A; Internal heavy atom effect; Intersystem crossing
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Year: 2013 PMID： 23978649 DOI： 10.1016/j.bmcl.2013.07.064
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823