Literature DB >> 23975928

Discovery of the cellular and molecular basis of cholesterol control.

Randy Schekman1.   

Abstract

The cellular control of cholesterol metabolism mediated by lipoproteins was first appreciated in pioneering work published in a 1974 PNAS Classic by Michael Brown and Joseph Goldstein. We know from this paper that the LDL binds to a cell surface receptor and dampens the activity of a key enzyme in cholesterol biosynthesis and that a receptor deficiency is responsible for a major genetic cause of hypercholesterolemia and premature atherosclerosis.

Entities:  

Keywords:  HMG-CoA; endocytosis; lysosome; reductase

Mesh：

Substances：

Year:  2013        PMID： 23975928      PMCID： PMC3773783          DOI： 10.1073/pnas.1312967110

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

1.  Coated vesicles from pig brain: purification and biochemical characterization.

Authors:  B M Pearse
Journal:  J Mol Biol       Date:  1975-09-05       Impact factor: 5.469

2.  A recognition marker required for uptake of a lysosomal enzyme by cultured fibroblasts.

Authors:  S Hickman; L J Shapiro; E F Neufeld
Journal:  Biochem Biophys Res Commun       Date:  1974-03-15       Impact factor: 3.575

3.  Affinity chromatography and purification of the insulin receptor of liver cell membranes.

Authors:  P Cuatrecasas
Journal:  Proc Natl Acad Sci U S A       Date:  1972-05       Impact factor: 11.205

4.  The role of sialic acid in determining the survival of glycoproteins in the circulation.

Authors:  A G Morell; G Gregoriadis; I H Scheinberg; J Hickman; G Ashwell
Journal:  J Biol Chem       Date:  1971-03-10       Impact factor: 5.157

Review 5.  Sterol trafficking between the endoplasmic reticulum and plasma membrane in yeast.

Authors:  D P Sullivan; H Ohvo-Rekilä; N A Baumann; C T Beh; A K Menon
Journal:  Biochem Soc Trans       Date:  2006-06       Impact factor: 5.407

6.  Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts by lipoproteins.

Authors:  M S Brown; S E Dana; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1973-07       Impact factor: 11.205

7.  Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.

Authors:  Li-Ping Sun; Joachim Seemann; Joseph L Goldstein; Michael S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2007-04-11       Impact factor: 11.205

8.  Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts.

Authors:  A Kaplan; D T Achord; W S Sly
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

9.  Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.

Authors:  Sumana Raychaudhuri; Young Jun Im; James H Hurley; William A Prinz
Journal:  J Cell Biol       Date:  2006-04-03       Impact factor: 10.539

10.  YOLK PROTEIN UPTAKE IN THE OOCYTE OF THE MOSQUITO AEDES AEGYPTI. L.

Authors:  T F ROTH; K R PORTER
Journal:  J Cell Biol       Date:  1964-02       Impact factor: 10.539
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  8 in total

1.  Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol.

Authors:  Wensi Tao; Robert Moore; Yue Meng; Elizabeth R Smith; Xiang-Xi Xu
Journal:  J Lipid Res       Date:  2016-03-22       Impact factor: 5.922

Review 2.  Cholesterol Metabolic Reprogramming in Cancer and Its Pharmacological Modulation as Therapeutic Strategy.

Authors:  Isabella Giacomini; Federico Gianfanti; Maria Andrea Desbats; Genny Orso; Massimiliano Berretta; Tommaso Prayer-Galetti; Eugenio Ragazzi; Veronica Cocetta
Journal:  Front Oncol       Date:  2021-05-24       Impact factor: 6.244

Review 3.  Emerging Role of Genomic Analysis in Clinical Evaluation of Lean Individuals With NAFLD.

Authors:  Sílvia Vilarinho; Veeral Ajmera; Melanie Zheng; Rohit Loomba
Journal:  Hepatology       Date:  2021-10       Impact factor: 17.298

4.  Genetic changes of Plasmodium vivax tempers host tissue-specific responses in Anopheles stephensi.

Authors:  Seena Kumari; Charu Chauhan; Sanjay Tevatiya; Deepak Singla; Tanwee Das De; Punita Sharma; Tina Thomas; Jyoti Rani; Deepali Savargaonkar; Kailash C Pandey; Veena Pande; Rajnikant Dixit
Journal:  Curr Res Immunol       Date:  2021-02-20

5.  Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

Authors:  Yaqi Wang; Ting Wu; Danqing Hu; Xinxin Weng; Xiaojing Wang; Pei-Jer Chen; Xiaoping Luo; Hongwu Wang; Qin Ning
Journal:  J Lipid Res       Date:  2017-11-13       Impact factor: 5.922

Review 6.  Opinion: On the Way towards the New Paradigm of Atherosclerosis.

Authors:  Alexander A Mironov; Galina V Beznoussenko
Journal:  Int J Mol Sci       Date:  2022-02-15       Impact factor: 5.923

7.  Effects of Methanol Extract of Breadfruit (Artocarpus altilis) on Atherogenic Indices and Redox Status of Cellular System of Hypercholesterolemic Male Rats.

Authors:  Oluwatosin Adekunle Adaramoye; Olubukola Oyebimpe Akanni
Journal:  Adv Pharmacol Sci       Date:  2014-01-30

8.  Loss of Calreticulin Uncovers a Critical Role for Calcium in Regulating Cellular Lipid Homeostasis.

Authors:  Wen-An Wang; Wen-Xin Liu; Serpen Durnaoglu; Sun-Kyung Lee; Jihong Lian; Richard Lehner; Joohong Ahnn; Luis B Agellon; Marek Michalak
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379
  8 in total

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