| Literature DB >> 23975368 |
Xionghui Mao1, Susheng Miao, Hongjiang He, Suping Miao, Rong Pei, Xianguang Yang, Chen Xiu, Kaibin Song, Jian Zhang, Ji Sun, Shenshan Jia, Qiang Guan.
Abstract
Krüppel-like factor 5 (KLF5), a zinc finger-containing transcription factor, is involved in important biological processes including cell transformation, proliferation, and carcinogenesis. However, its clinical significance has remained largely unknown in laryngeal cancer. Here, specimens from 144 patients with laryngeal tumors were investigated by immunohistochemical staining for KLF5, integrin-linked kinase (ILK), and E-cadherin expressions. A clinicopathological study revealed that the KLF5 expression level in tumor cells was significantly correlated with lymph node metastasis (P < 0.05) and local recurrence (P < 0.05). In addition, KLF5, ILK, and E-cadherin (epithelial-mesenchymal transition (EMT) biomarker) expressions were correlated with each other. These findings suggest that KLF5 may be an epithelial-mesenchymal transition-associated biomarker in human laryngeal carcinomas and play important roles in the progression of laryngeal carcinomas. KLF5 immunoreactivity is therefore considered a potential lymph node metastasis and recurrence factor in human laryngeal cancers. In addition, the KLF5-mediated pathway is a potential target for elimination of laryngeal cancer in the future.Entities:
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Year: 2013 PMID： 23975368 DOI： 10.1007/s13277-013-1086-3
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283