RATIONALE: There is a significant delay in the clinical response of antidepressant drugs, and antidepressant treatments produce side effects. OBJECTIVE: We examined the relationship between 17β-estradiol and topiramate in ovariectomized Wistar rats submitted to the forced swimming test (FST). METHODS: Topiramate was administered alone or combined with 17β-estradiol to ovariectomized rats submitted to the FST. RESULTS: Topiramate (20 mg/kg, P < 0.05; 30 mg/kg, P < 0.05) reduced immobility by increasing swimming; these effects were antagonized by finasteride (50 mg/kg). In interaction experiments, topiramate (10 mg/kg) plus 17β-estradiol (5 micrograms per rat; P < 0.05) reduced immobility by increasing swimming behavior. Besides, 17β-estradiol (2.5 micrograms per rat) shortened the onset of the antidepressant-like effects of topiramate (P < 0.05). In the open field test, topiramate alone or combined with 17β-estradiol (P < 0.05) reduced locomotion. CONCLUSIONS: Topiramate alone or combined with 17β-estradiol produced antidepressant-like actions; and 17β-estradiol shortened the onset of the antidepressant-like effects of topiramate.
RATIONALE: There is a significant delay in the clinical response of antidepressant drugs, and antidepressant treatments produce side effects. OBJECTIVE: We examined the relationship between 17β-estradiol and topiramate in ovariectomized Wistar rats submitted to the forced swimming test (FST). METHODS:Topiramate was administered alone or combined with 17β-estradiol to ovariectomized rats submitted to the FST. RESULTS:Topiramate (20 mg/kg, P < 0.05; 30 mg/kg, P < 0.05) reduced immobility by increasing swimming; these effects were antagonized by finasteride (50 mg/kg). In interaction experiments, topiramate (10 mg/kg) plus 17β-estradiol (5 micrograms per rat; P < 0.05) reduced immobility by increasing swimming behavior. Besides, 17β-estradiol (2.5 micrograms per rat) shortened the onset of the antidepressant-like effects of topiramate (P < 0.05). In the open field test, topiramate alone or combined with 17β-estradiol (P < 0.05) reduced locomotion. CONCLUSIONS:Topiramate alone or combined with 17β-estradiol produced antidepressant-like actions; and 17β-estradiol shortened the onset of the antidepressant-like effects of topiramate.
Authors: Elena Castro; Alvaro Díaz; Antonio Rodriguez-Gaztelumendi; Elena Del Olmo; Angel Pazos Journal: Neuropharmacology Date: 2008-09-17 Impact factor: 5.250
Authors: Cerstin Nickel; Claas Lahmann; Karin Tritt; Moritz Muehlbacher; Patrick Kaplan; Christian Kettler; Jakub Krawczyk; Thomas H Loew; Wolfhardt K Rother; Marius K Nickel Journal: J Affect Disord Date: 2005-08 Impact factor: 4.839
Authors: E Romeo; A Ströhle; G Spalletta; F di Michele; B Hermann; F Holsboer; A Pasini; R Rupprecht Journal: Am J Psychiatry Date: 1998-07 Impact factor: 18.112