Literature DB >> 23975032

Studying the human immunome: the complexity of comprehensive leukocyte immunophenotyping.

Angélique Biancotto1, J Philip McCoy.   

Abstract

A comprehensive study of the cellular components of the immune system requires both deep and broad immunophenotyping of numerous cell populations in an efficient and practical manner. In this chapter, we describe the technical aspects of studying the human immunome using high-dimensional (15 color) fluorescence-based immunophenotyping. We focus on the technical aspects of polychromatic flow cytometry and the initial stages in developing a panel for comprehensive leukocyte immunophenotyping (CLIP). We also briefly discuss how this panel is being used and the challenges of encyclopedic analysis of these rich data sets.

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Year:  2014        PMID： 23975032      PMCID： PMC4184245          DOI： 10.1007/82_2013_336

Source DB:  PubMed          Journal:  Curr Top Microbiol Immunol        ISSN： 0070-217X            Impact factor:   4.291


  39 in total

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