PURPOSE: The aim of this study was to analyze the outcomes of children added to the waiting list for deceased donor liver transplantation (DDLT) and the results of DDLT in a single Japanese center. METHODS: Forty-seven children were listed on the organ allocation system for DDLT. The priority points related to the medical status of each patient were evaluated and stratified into four categories; 10, 8, 6, and 3 points. The clinical data were collected from the medical records, and the outcomes were analyzed. RESULTS: There were 10 priority points in 25 patients, 6 points in 13 and 3 points in 9. Ten recipients (21.3 %); 7 patients with 10 points and 3 patients with 6 points, underwent DDLT. Seven out of the 10 recipients received split/reduced liver grafts. The surgical complications consisted of biliary stricture, hepatic venous outflow obstruction, intraabdominal abscess and intraabdominal bleeding. Two recipients, who were critically-ill before DDLT, died due to sepsis. The one-year graft survival rate was 70.0 %, with a median follow-up period of 6.4 months. CONCLUSION: The initial experience with pediatric DDLT in our series was satisfactory. Split LT of deceased donor organs may have the potential to resolve the serious organ shortage in Japan.
PURPOSE: The aim of this study was to analyze the outcomes of children added to the waiting list for deceased donor liver transplantation (DDLT) and the results of DDLT in a single Japanese center. METHODS: Forty-seven children were listed on the organ allocation system for DDLT. The priority points related to the medical status of each patient were evaluated and stratified into four categories; 10, 8, 6, and 3 points. The clinical data were collected from the medical records, and the outcomes were analyzed. RESULTS: There were 10 priority points in 25 patients, 6 points in 13 and 3 points in 9. Ten recipients (21.3 %); 7 patients with 10 points and 3 patients with 6 points, underwent DDLT. Seven out of the 10 recipients received split/reduced liver grafts. The surgical complications consisted of biliary stricture, hepatic venous outflow obstruction, intraabdominal abscess and intraabdominal bleeding. Two recipients, who were critically-ill before DDLT, died due to sepsis. The one-year graft survival rate was 70.0 %, with a median follow-up period of 6.4 months. CONCLUSION: The initial experience with pediatric DDLT in our series was satisfactory. Split LT of deceased donor organs may have the potential to resolve the serious organ shortage in Japan.
Authors: W R Kim; P G Stock; J M Smith; J K Heimbach; M A Skeans; E B Edwards; A M Harper; J J Snyder; A K Israni; B L Kasiske Journal: Am J Transplant Date: 2013-01 Impact factor: 8.086
Authors: Jean C Emond; Richard B Freeman; John F Renz; Hasan Yersiz; Xavier Rogiers; Ronald W Busuttil Journal: Liver Transpl Date: 2002-10 Impact factor: 5.799
Authors: K Ozawa; S Uemoto; K Tanaka; K Kumada; Y Yamaoka; N Kobayashi; T Inamoto; Y Shimahara; K Mori; K Honda Journal: Ann Surg Date: 1992-11 Impact factor: 12.969
Authors: Johnny C Hong; Hasan Yersiz; Douglas G Farmer; John P Duffy; R Mark Ghobrial; Bunthoon Nonthasoot; Thomas E Collins; Jonathan R Hiatt; Ronald W Busuttil Journal: J Am Coll Surg Date: 2009-03-26 Impact factor: 6.113
Authors: K Tanaka; S Uemoto; Y Tokunaga; S Fujita; K Sano; T Nishizawa; H Sawada; I Shirahase; H J Kim; Y Yamaoka Journal: Ann Surg Date: 1993-01 Impact factor: 12.969
Authors: Andrea Lauterio; Stefano Di Sandro; Giacomo Concone; Riccardo De Carlis; Alessandro Giacomoni; Luciano De Carlis Journal: World J Gastroenterol Date: 2015-10-21 Impact factor: 5.742