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Literature DB >> 23974133

Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC.

Ramesh Prasad Pandey¹, Prakash Parajuli, Niranjan Koirala, Je Won Park, Jae Kyung Sohng.

Abstract

The glycosylation of five different flavonols, fisetin, quercetin, myricetin, kaempferol, and 3-hydroxyflavone, was achieved by applying YjiC. 3-Hydroxyflavone was selected as a probe for in vitro glycorandomization of all flavonols using diverse nucleotide diphosphate-d/l-sugars. This study unlocked the possibilities of the glycodiversification of flavonols and the generation of novel compounds as future therapeutics.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23974133 PMCID： PMC3811512 DOI： 10.1128/AEM.02057-13

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

29 in total

1. Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization.

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Journal: Org Lett Date: 2003-03-20 Impact factor: 6.005

2. Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides.

Authors: Eng-Kiat Lim; David A Ashford; Bingkai Hou; Rosamond G Jackson; Dianna J Bowles
Journal: Biotechnol Bioeng Date: 2004-09-05 Impact factor: 4.530

3. Diversifying vancomycin via chemoenzymatic strategies.

Authors: Xun Fu; Christoph Albermann; Changsheng Zhang; Jon S Thorson
Journal: Org Lett Date: 2005-04-14 Impact factor: 6.005

4. The synthesis of small-molecule rhamnosides through the rational design of a whole-cell biocatalysis system.

Authors: Eng-Kiat Lim; David A Ashford; Dianna J Bowles
Journal: Chembiochem Date: 2006-08 Impact factor: 3.164

Review 5. The role of carbohydrates in biologically active natural products.

Authors: A C Weymouth-Wilson
Journal: Nat Prod Rep Date: 1997-04 Impact factor: 13.423

6. Enzymatic synthesis of novel phloretin glucosides.

Authors: Ramesh Prasad Pandey; Tai Feng Li; Eun-Hee Kim; Tokutaro Yamaguchi; Yong Il Park; Joong Su Kim; Jae Kyung Sohng
Journal: Appl Environ Microbiol Date: 2013-03-29 Impact factor: 4.792

7. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries.

Authors: S H Häkkinen; S O Kärenlampi; I M Heinonen; H M Mykkänen; A R Törrönen
Journal: J Agric Food Chem Date: 1999-06 Impact factor: 5.279

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Authors: V Kren; L Martínková
Journal: Curr Med Chem Date: 2001-09 Impact factor: 4.530

9. Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.

Authors: Joseph M Langenhan; Noël R Peters; Ilia A Guzei; F Michael Hoffmann; Jon S Thorson
Journal: Proc Natl Acad Sci U S A Date: 2005-08-16 Impact factor: 11.205

10. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies.

Authors: R R Huxley; H A W Neil
Journal: Eur J Clin Nutr Date: 2003-08 Impact factor: 4.016

10 in total

Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC.

1. Substrate specificity of NovM: implications for novobiocin biosynthesis and glycorandomization.

2. Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides.

3. Diversifying vancomycin via chemoenzymatic strategies.

4. The synthesis of small-molecule rhamnosides through the rational design of a whole-cell biocatalysis system.

Review 5. The role of carbohydrates in biologically active natural products.

6. Enzymatic synthesis of novel phloretin glucosides.

7. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries.

Review 8. Glycosides in medicine: "The role of glycosidic residue in biological activity".

9. Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization.

10. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies.

1. Enzymatic glycosylation of the topical antibiotic mupirocin.

2. Modification of emodin and aloe-emodin by glycosylation in engineered Escherihia coli.

3. Enzymatic Biosynthesis of Novel Resveratrol Glucoside and Glycoside Derivatives.

4. Enzymatic synthesis of lactosylated and sialylated derivatives of epothilone A.

5. Excited state proton transfer of natural flavonoids and their chromophores in duplex and tetraplex DNAs.

6. Glycosylation of 3-Hydroxyflavone, 3-Methoxyflavone, Quercetin and Baicalein in Fungal Cultures of the Genus Isaria.

7. Glucosylation of isoflavonoids in engineered Escherichia coli.

8. Enzymatic synthesis of epothilone A glycosides.

9. Dietary flavonoid fisetin binds human SUMO1 and blocks sumoylation of p53.

Review 10. Recent Advances in the Metabolic Engineering of Yeasts for Ginsenoside Biosynthesis.