| Literature DB >> 23973312 |
Jun Yang1, Ming-Xing Li2, Yi Luo3, Tao Chen4, Jing Liu5, Peng Fang6, Bo Jiang7, Zhuang-Li Hu8, You Jin9, Jian-Guo Chen10, Fang Wang11.
Abstract
Aquaporin-4 (AQP4) is the predominant water channel protein in the mammalian brain, and is mainly expressed in astrocytes. Besides its important role in water transport across the blood-brain barrier, our present study demonstrated that AQP4 deficiency impaired hippocampal long-term potentiation (LTP) and hippocampus-dependent memory formation, accompanied by the increase in extracellular glutamate concentration and N-methyl-d-aspartate (NMDA) receptor-mediated currents in hippocampal dentate gyrus (DG) region. The impairment of LTP and memory formation of AQP4 knockout (KO) mice was mediated by the downregulation of glutamate transporter-1 (GLT-1) expression/function, since it can be rescued by β-lactam antibiotic ceftriaxone (Cef), a potent GLT-1 stimulator. These results suggest that AQP4 functions as the modulator of synaptic plasticity and memory, and chronic Cef treatment rescues hippocampal memory deficit induced by AQP4 knockout.Entities:
Keywords: 6-cyano-7- nitroquinoxaline-2, 3-dione; ACSF; AMPA; AQP4; BSA; CNQX; Cef; Ceftriaxone; DG; DL-APV; DL-aminophosphonovaleric acid; EPSCs; GLT-1; HPLC-ECD; KO; LTP; Long-term potentiation; Memory; N-methyl-d-aspartate; NMDA; PBS; PP; PS; TBS; aquaporin-4; artificial cerebrospinal fluid; bovine serum albumin; dentate gyrus; excitatory postsynaptic currents; fEPSP; field excitatory postsynaptic potential; glutamate transporter-1; knockout; long-term potentiation; perforant path; phosphate-buffered saline; population spike; reverse-phase HPLC coupled to electrochemical detection; theta-burst stimulation; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
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Year: 2013 PMID： 23973312 DOI： 10.1016/j.neuropharm.2013.08.009
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250