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Literature DB >> 23973217

Generating CD8 T cell heterogeneity: attack of the clones.

Abstract

Pathogen-induced inflammation modulates CD8 T cell effector and memory differentiation. In this issue of Immunity, Plumlee et al. (2013) demonstrate that clonally distinct CD8 T cells have the ability to generate numerous types of effector cell fates based on extrinsic pathogen-induced environmental cues.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23973217 PMCID： PMC4382630 DOI： 10.1016/j.immuni.2013.08.008

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

10 in total

1. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells.

Authors: Nikhil S Joshi; Weiguo Cui; Claudia X Dominguez; Jonathan H Chen; Timothy W Hand; Susan M Kaech
Journal: J Immunol Date: 2011-09-19 Impact factor: 5.422

2. Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

Authors: John T Chang; Vikram R Palanivel; Ichiko Kinjyo; Felix Schambach; Andrew M Intlekofer; Arnob Banerjee; Sarah A Longworth; Kristine E Vinup; Paul Mrass; Jane Oliaro; Nigel Killeen; Jordan S Orange; Sarah M Russell; Wolfgang Weninger; Steven L Reiner
Journal: Science Date: 2007-03-01 Impact factor: 47.728

3. Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.

Authors: Fabrice Lemaître; Hélène D Moreau; Laura Vedele; Philippe Bousso
Journal: J Immunol Date: 2013-07-08 Impact factor: 5.422

4. Heterogeneous differentiation patterns of individual CD8+ T cells.

Authors: Carmen Gerlach; Jan C Rohr; Leïla Perié; Nienke van Rooij; Jeroen W J van Heijst; Arno Velds; Jos Urbanus; Shalin H Naik; Heinz Jacobs; Joost B Beltman; Rob J de Boer; Ton N M Schumacher
Journal: Science Date: 2013-03-14 Impact factor: 47.728

1 in total

1. [Oxidized low-density lipoprotein modulates differentiation of murine memory CD8⁺ T cell subpopulations].

Authors: Hua Zheng; Ze-Hang Lin; Yan-Mei Zhang; Chen-Fei Zhou; Xuan Liu; Sha Wu
Journal: Nan Fang Yi Ke Da Xue Xue Bao Date: 2017-08-20

1 in total

Generating CD8 T cell heterogeneity: attack of the clones.

1. Increased numbers of preexisting memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells.

2. Asymmetric T lymphocyte division in the initiation of adaptive immune responses.

3. Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division.

4. Heterogeneous differentiation patterns of individual CD8+ T cells.

5. Disparate individual fates compose robust CD8+ T cell immunity.

6. Environmental cues dictate the fate of individual CD8+ T cells responding to infection.

7. Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection.

8. T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.

Review 9. Transcriptional control of effector and memory CD8+ T cell differentiation.

10. Complete but curtailed T-cell response to very low-affinity antigen.

1. [Oxidized low-density lipoprotein modulates differentiation of murine memory CD8⁺ T cell subpopulations].