| Literature DB >> 23973169 |
Tao Zhou1, Robert C Hider, Peter Jenner, Bruce Campbell, Christopher J Hobbs, Sarah Rose, Mark Jairaj, Kayhan A Tayarani-Binazir, Alexander Syme.
Abstract
A series of dipeptide derivatives of L-dopa were synthesized and investigated for their pharmacological activity using the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat as an experimental model of Parkinson's disease. Among them, (S)-isopropyl 2-(2-amino-2-methylpropanamido)-3-(3,4-dihydroxyphenyl)propanoate (4 g) was found to be the most active compound, with 106% AUC activity and 149% peak activity of L-dopa after oral administration.Entities:
Keywords: 6-Hydroxydopamine (6-OHDA) lesioned rat; Parkinson’s disease; Prodrug; l-Dopa
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Year: 2013 PMID： 23973169 DOI： 10.1016/j.bmcl.2013.08.007
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823