Literature DB >> 23972788

Genetic polymorphisms in the PACAP and PAC1 receptor genes and treatment response to venlafaxine XR in generalized anxiety disorder.

Alissa J Cooper1, Sneha Narasimhan, Karl Rickels, Falk W Lohoff.   

Abstract

The pituitary adenylate cyclase-activating peptide (PACAP) and its receptor (PAC1) are involved in stress response and anxiety. Genotypes for PACAP/PAC1 were examined for effects on treatment response to venlafaxine XR in generalized anxiety disorder. The Asp54Gly (rs2856966) variant in the PACAP gene was associated with better treatment outcome.
© 2013 Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Anxiety disorders; Hypothalamic–pituitary–adrenal axis; Pharmacogenetics

Mesh：

Substances：

Year:  2013        PMID： 23972788     DOI： 10.1016/j.psychres.2013.07.038

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  8 in total

1.  PACAP increases Arc/Arg 3.1 expression within the extended amygdala after fear conditioning in rats.

Authors:  Edward G Meloni; Karen T Kaye; Archana Venkataraman; William A Carlezon
Journal:  Neurobiol Learn Mem       Date:  2018-11-17       Impact factor: 2.877

Review 2.  Pleiotropic pituitary adenylate cyclase-activating polypeptide (PACAP): Novel insights into the role of PACAP in eating and drug intake.

Authors:  Andrew T Gargiulo; Genevieve R Curtis; Jessica R Barson
Journal:  Brain Res       Date:  2019-12-26       Impact factor: 3.252

Review 3.  Long-Term Pharmacological Treatments of Anxiety Disorders: An Updated Systematic Review.

Authors:  Giampaolo Perna; Alessandra Alciati; Alice Riva; Wilma Micieli; Daniela Caldirola
Journal:  Curr Psychiatry Rep       Date:  2016-03       Impact factor: 5.285

4.  Circulating PACAP peptide and PAC1R genotype as possible transdiagnostic biomarkers for anxiety disorders in women: a preliminary study.

Authors:  Rachel A Ross; Susanne S Hoeppner; Samantha N Hellberg; Emily B O'Day; Peter L Rosencrans; Kerry J Ressler; Víctor May; Naomi M Simon
Journal:  Neuropsychopharmacology       Date:  2020-01-07       Impact factor: 8.294

Review 5.  Biological predictors of pharmacological therapy in anxiety disorders.

Authors:  Eduard Maron; David Nutt
Journal:  Dialogues Clin Neurosci       Date:  2015-09       Impact factor: 5.986

6.  Beneficial Effects of Crocin against Depression via Pituitary Adenylate Cyclase-Activating Polypeptide.

Authors:  Linyu Lu; Die Wu; Kai Wang; Juanjuan Tang; Gang Chen
Journal:  Biomed Res Int       Date:  2020-06-24       Impact factor: 3.411

Review 7.  Biological markers of generalized anxiety disorder.

Authors:  Eduard Maron; David Nutt
Journal:  Dialogues Clin Neurosci       Date:  2017-06       Impact factor: 5.986

8.  Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior.

Authors:  Jakob Biran; Michael Gliksberg; Ido Shirat; Amrutha Swaminathan; Talia Levitas-Djerbi; Lior Appelbaum; Gil Levkowitz
Journal:  Sci Rep       Date:  2020-06-12       Impact factor: 4.379
  8 in total

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