Hidetaka Noma1, Tatsuya Mimura. 1. Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University , Chiba , Japan and.
Abstract
PURPOSE/AIM: The aqueous humor level of soluble vascular endothelial growth factor receptor (sVEGFR)-2 may influence macular edema in patients with branch retinal vein occlusion (BRVO). The association of sVEGFR-2 with macular edema was investigated in this study. MATERIALS AND METHODS: A retrospective case-controlled study was performed in 22 patients with BRVO and macular edema, as well as 5 patients with non-ischemic ocular diseases as the control group. The severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained during intravitreous injection of anti-VEGF agents, triamcinolone acetonide, or combined vitrectomy and cataract surgery. sVEGFR-2 levels in aqueous humor were determined by enzyme-linked immunosorbent assay. RESULTS: The aqueous humor level of sVEGFR-2 (median: 124.5 ng/ml) was significantly elevated in BRVO patients compared with the control group (78.1 pg/ml) (p = 0.010). In addition, the sVEGFR-2 level was correlated with the severity of macular edema (p = 0.033). CONCLUSIONS: sVEGFR-2 may be involved in the pathogenesis of macular edema associated with BRVO. Measurement of aqueous humor sVEGFR-2 levels may be helpful for understanding the disease status in BRVO patients with macular edema.
PURPOSE/AIM: The aqueous humor level of soluble vascular endothelial growth factor receptor (sVEGFR)-2 may influence macular edema in patients with branch retinal vein occlusion (BRVO). The association of sVEGFR-2 with macular edema was investigated in this study. MATERIALS AND METHODS: A retrospective case-controlled study was performed in 22 patients with BRVO and macular edema, as well as 5 patients with non-ischemic ocular diseases as the control group. The severity of macular edema was examined by optical coherence tomography. Aqueous humor samples were obtained during intravitreous injection of anti-VEGF agents, triamcinolone acetonide, or combined vitrectomy and cataract surgery. sVEGFR-2 levels in aqueous humor were determined by enzyme-linked immunosorbent assay. RESULTS: The aqueous humor level of sVEGFR-2 (median: 124.5 ng/ml) was significantly elevated in BRVO patients compared with the control group (78.1 pg/ml) (p = 0.010). In addition, the sVEGFR-2 level was correlated with the severity of macular edema (p = 0.033). CONCLUSIONS: sVEGFR-2 may be involved in the pathogenesis of macular edema associated with BRVO. Measurement of aqueous humor sVEGFR-2 levels may be helpful for understanding the disease status in BRVO patients with macular edema.
Authors: Lasse Jørgensen Cehofski; Kentaro Kojima; Nobuhiro Terao; Koji Kitazawa; Sasikala Thineshkumar; Jakob Grauslund; Henrik Vorum; Bent Honoré Journal: Invest Ophthalmol Vis Sci Date: 2020-12-01 Impact factor: 4.799