Literature DB >> 2397086

Plasma and CSF tryptophan in cancer anorexia.

C Cangiano1, A Cascino, F Ceci, A Laviano, M Mulieri, M Muscaritoli, F Rossi-Fanelli.   

Abstract

Eighteen untreated cancer patients and ten sex- and age-matched healthy volunteers were studied. In all patients eating behavior was investigated by means of a specific questionnaire from which the presence of anorexia and anorexia-related symptoms was assessed. To investigate the role of tryptophan in cancer anorexia, fasting plasma and CSF levels of tryptophan and other neutral amino acids were assayed in patients and controls. Cancer patients showed abnormally high plasma free tryptophan levels. In case of patients with cancer anorexia a significant rise of the ratio in plasma between free and tryptophan/large neutral amino acids, competing with tryptophan for its brain entry, was observed. This increase was correlated to a consistent rise of CSF tryptophan levels suggesting a specific role of the serotoninergic system in the pathogenesis of cancer anorexia.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2397086     DOI： 10.1007/bf01245044

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  22 in total

1.  Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure.

Authors:  D L Bloxam; W H Warren
Journal:  Anal Biochem       Date:  1974-08       Impact factor: 3.365

2.  Effect of increased rat brain tryptophan on 5-hydroxytryptamine and 5-hydroxyindolyl acetic acid in the hypothalamus and other brain regions.

Authors:  P J Knott; G Curzon
Journal:  J Neurochem       Date:  1974-06       Impact factor: 5.372

3.  A central mechanism for anorexia in cancer: a hypothesis.

Authors:  R Krause; C Humphrey; M von Meyenfeldt; H James; J E Fischer
Journal:  Cancer Treat Rep       Date:  1981

4.  Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats.

Authors:  J J Wurtman; R J Wurtman
Journal:  Science       Date:  1977-12-16       Impact factor: 47.728

5.  The determination of tryptophan in plasma, liver, and urine.

Authors:  W D Denckla; H K Dewey
Journal:  J Lab Clin Med       Date:  1967-01

6.  On the stimulation by insulin of tryptophan transport across the blood-brain barrier.

Authors:  C Cangiano; P Cardelli-Cangiano; A Cascino; M A Patrizi; F Barberini; F Rossi Fanelli; L Capocaccia; R Strom
Journal:  Biochem Int       Date:  1983-11

7.  Plasma amino acids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements.

Authors:  B Caballero; N Finer; R J Wurtman
Journal:  Metabolism       Date:  1988-07       Impact factor: 8.694

8.  Plasma tryptophan and anorexia in human cancer.

Authors:  F Rossi Fanelli; C Cangiano; F Ceci; R Cellerino; F Franchi; E T Menichetti; M Muscaritoli; A Cascino
Journal:  Eur J Cancer Clin Oncol       Date:  1986-01

9.  Hyperphagia and obesity following serotonin depletion by intraventricular p-chlorophenylalanine.

Authors:  S T Breisch; F P Zemlan; B G Hoebel
Journal:  Science       Date:  1976-04-23       Impact factor: 47.728

10.  Hypothalamic control of food intake in rats and cats.

Authors:  B K ANAND; J R BROBECK
Journal:  Yale J Biol Med       Date:  1951-11
View more
  12 in total

Review 1.  Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy.

Authors:  Thomas W Buford; Stephen D Anton; Andrew R Judge; Emanuele Marzetti; Stephanie E Wohlgemuth; Christy S Carter; Christiaan Leeuwenburgh; Marco Pahor; Todd M Manini
Journal:  Ageing Res Rev       Date:  2010-05-14       Impact factor: 10.895

Review 2.  Anorexia in older persons: epidemiology and optimal treatment.

Authors:  J E Morley
Journal:  Drugs Aging       Date:  1996-02       Impact factor: 3.923

Review 3.  A hunger for hunger: a review of palliative therapies for cancer-associated anorexia.

Authors:  Daniel S Childs; Aminah Jatoi
Journal:  Ann Palliat Med       Date:  2018-05-24

4.  Differences in food intake of tumour-bearing cachectic mice are associated with hypothalamic serotonin signalling.

Authors:  Jvalini T Dwarkasing; Mark V Boekschoten; Joseph M Argilès; Miriam van Dijk; Silvia Busquets; Fabio Penna; Miriam Toledo; Alessandro Laviano; R F Witkamp; Klaske van Norren
Journal:  J Cachexia Sarcopenia Muscle       Date:  2015-03-31       Impact factor: 12.910

Review 5.  The end of the road for the tryptophan depletion concept in pregnancy and infection.

Authors:  Abdulla A-B Badawy; Aryan M A Namboodiri; John R Moffett
Journal:  Clin Sci (Lond)       Date:  2016-08-01       Impact factor: 6.124

6.  Plasma metabolome and skin proteins in Charcot-Marie-Tooth 1A patients.

Authors:  Beatriz Soldevilla; Carmen Cuevas-Martín; Clara Ibáñez; Fulvio Santacatterina; María A Alberti; Carolina Simó; Carlos Casasnovas; Celedonio Márquez-Infante; Teresa Sevilla; Samuel I Pascual; María Sánchez-Aragó; Carmen Espinos; Francesc Palau; José M Cuezva
Journal:  PLoS One       Date:  2017-06-02       Impact factor: 3.240

7.  Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer.

Authors:  A Huang; D Fuchs; B Widner; C Glover; D C Henderson; T G Allen-Mersh
Journal:  Br J Cancer       Date:  2002-06-05       Impact factor: 7.640

Review 8.  Pancreatic cancer cachexia: a review of mechanisms and therapeutics.

Authors:  Carlyn R Tan; Patrick M Yaffee; Laith H Jamil; Simon K Lo; Nicholas Nissen; Stephen J Pandol; Richard Tuli; Andrew E Hendifar
Journal:  Front Physiol       Date:  2014-03-03       Impact factor: 4.566

Review 9.  Contribution of Neuroinflammation to the Pathogenesis of Cancer Cachexia.

Authors:  Alessio Molfino; Gianfranco Gioia; Filippo Rossi Fanelli; Alessandro Laviano
Journal:  Mediators Inflamm       Date:  2015-10-04       Impact factor: 4.711

Review 10.  Pathophysiology of anorexia in the cancer cachexia syndrome.

Authors:  Chukwuemeka Charles Ezeoke; John E Morley
Journal:  J Cachexia Sarcopenia Muscle       Date:  2015-10-27       Impact factor: 12.910
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.