Literature DB >> 23970582

Iatrogenic Cushing syndrome after intra-articular triamcinolone in a patient receiving ritonavir-boosted darunavir.

Jill J Hall1, Christine A Hughes, Michelle M Foisy, Stan Houston, Stephen Shafran.   

Abstract

Drug interactions involving human immunodeficiency virus protease inhibitors are common due to their inhibition of the cytochrome P450 3A4 isoenzyme. We describe the case of an HIV-infected patient treated with ritonavir-boosted darunavir who developed cushingoid features following an intra-articular injection of triamcinolone acetate. We review the probable mechanism for this interaction and describe similar cases of Cushing syndrome in patients receiving concomitant ritonavir and triamcinolone.

Entities:  

Keywords:  AIDS; Cushing syndrome; HIV; HIV protease inhibitors; antiretrovirals; cobicistat; corticosteroids; drug interactions; ritonavir; toxicity; triamcinolone

Mesh：

Substances：

Year:  2013        PMID： 23970582     DOI： 10.1177/0956462413480723

Source DB:  PubMed          Journal:  Int J STD AIDS        ISSN： 0956-4624            Impact factor:   1.359


  10 in total

1.  Exogenous steroid-induced hypoadrenalism in a person living with HIV caused by a drug-drug interaction between cobicistat and intrabursal triamcinolone.

Authors:  Navnit Makaram; Clark D Russell; Simon Benedict Roberts; Jarrad Stevens; Gavin Macpherson
Journal:  BMJ Case Rep       Date:  2018-12-14

2.  RAPID DEVELOPMENT OF IATROGENIC CUSHING SYNDROME IN A PATIENT ON RITONAVIR: THE ADVERSE METABOLIC CONSEQUENCE OF TOPICAL STEROID USE.

Authors:  Jeremy D Purser; Ruba Riachy; Lucas S Blanton; L Maria Belalcazar
Journal:  AACE Clin Case Rep       Date:  2020-09-24

Review 3.  Prescribing for patients taking antiretroviral therapy.

Authors:  Yasmin Hughes; Louise Tomlins; Tim Usherwood
Journal:  Aust Prescr       Date:  2022-06-01

4.  Iatrogenic Cushing's syndrome due to drug interaction between glucocorticoids and the ritonavir or cobicistat containing HIV therapies.

Authors:  Emilie R Elliot; Aikaterini Theodoraki; Lakshmi R Jain; Neal J Marshall; Marta Boffito; Stephanie E Baldeweg; Laura J Waters
Journal:  Clin Med (Lond)       Date:  2016-10       Impact factor: 2.659

Review 5.  Therapeutic Strategies for the Treatment of Severe Cushing's Syndrome.

Authors:  Krystallenia I Alexandraki; Ashley B Grossman
Journal:  Drugs       Date:  2016-03       Impact factor: 9.546

Review 6.  Iatrogenic cushing syndrome secondary to ritonavir-epidural triamcinolone interaction: an illustrative case and review.

Authors:  Sapna Sadarangani; Melody L Berg; William Mauck; Stacey Rizza
Journal:  Interdiscip Perspect Infect Dis       Date:  2014-05-07

Review 7.  Rheumatoid arthritis in patients with HIV: management challenges.

Authors:  Matthew B Carroll; Joshua H Fields; Philip G Clerc
Journal:  Open Access Rheumatol       Date:  2016-04-29

8.  Iatrogenic Cushing's Syndrome Following Intra-Articular Triamcinolone Injection in an HIV-Infected Patient on Cobicistat Presenting as a Pulmonary Embolism: Case Report and Literature Review.

Authors:  Marjan Alidoost; Gabriella A Conte; Khushboo Agarwal; Michael P Carson; Danielle Lann; Diane Marchesani
Journal:  Int Med Case Rep J       Date:  2020-06-09

Review 9.  Pharmacokinetic Drug-Drug Interactions Between Immunosuppressant and Anti-Infective Agents: Antimetabolites and Corticosteroids.

Authors:  Edward T Van Matre; Gowri Satyanarayana; Robert L Page 2nd; Marilyn E Levi; JoAnn Lindenfeld; Scott W Mueller
Journal:  Ann Transplant       Date:  2018-01-23       Impact factor: 1.530

Review 10.  What we have to know about corticosteroids use during Sars-Cov-2 infection.

Authors:  F Ferraù; F Ceccato; S Cannavò; C Scaroni
Journal:  J Endocrinol Invest       Date:  2020-08-28       Impact factor: 4.256
  10 in total

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