OBJECTIVE: The aim of this study was to identify factors associated with neuropsychological rehabilitation outcome in patients with multiple sclerosis (MS). METHODS:Ninety-eight relapsing-remitting MS patients received multimodal neuropsychological intervention (attention retraining, teaching compensatory strategies, psychoeducation, psychological support, and homework assignments) conducted once a week in 60-minute sessions during thirteen consecutive weeks. The evaluated factors included: 1) patient-related (baseline objective and subjective cognitive performance, mood, fatigue, as well as demographic factors); 2) illness-related (duration and severity of the disease); and 3) intervention-related factors (amount of computer-based attention exercises and homework assignments, therapist's evaluation of the benefit, and therapist). RESULTS: Patient-related factors affected rehabilitation outcome, whereas illness- and intervention-related factors did not. The results showed that especially MS patients with male gender and more severe attentional deficits benefitted from the intervention. CONCLUSION: Patient-related factors may affect neuropsychological rehabilitation outcome in MS.
RCT Entities:
OBJECTIVE: The aim of this study was to identify factors associated with neuropsychological rehabilitation outcome in patients with multiple sclerosis (MS). METHODS: Ninety-eight relapsing-remitting MSpatients received multimodal neuropsychological intervention (attention retraining, teaching compensatory strategies, psychoeducation, psychological support, and homework assignments) conducted once a week in 60-minute sessions during thirteen consecutive weeks. The evaluated factors included: 1) patient-related (baseline objective and subjective cognitive performance, mood, fatigue, as well as demographic factors); 2) illness-related (duration and severity of the disease); and 3) intervention-related factors (amount of computer-based attention exercises and homework assignments, therapist's evaluation of the benefit, and therapist). RESULTS:Patient-related factors affected rehabilitation outcome, whereas illness- and intervention-related factors did not. The results showed that especially MSpatients with male gender and more severe attentional deficits benefitted from the intervention. CONCLUSION:Patient-related factors may affect neuropsychological rehabilitation outcome in MS.
Authors: Lauren A Taylor; Jacqueline R Mhizha-Murira; Laura Smith; Kristy-Jane Potter; Dana Wong; Nikos Evangelou; Nadina B Lincoln; Roshan das Nair Journal: Cochrane Database Syst Rev Date: 2021-10-18