Literature DB >> 23968

Prostaglandins--modulation of adrenergic nervous system.

K U Malik.   

Abstract

Prostaglandins (PGs) affect vascular tone by a direct action on the vascular smooth muscle and by influencing vascular reactivity to adrenergic simuli and several vasoactive substances. Thus, in the isolated Tyrode's perfused rabbit renal, mesenteric and splenic vasculature PGE2 inhibited adrenergically induced vasoconstriction. Since the vasoconstrictor responses to renal nerve stimulation were enhanced by the blockade of PG synthesis and were reduced by stimulation of PG synthesis with arachidonic acid, this suggests that PGE2 functions as an inhibitory modulator of the adrenergic nervous system. However, our demonstration that PGE2 enhanced adrenergically induced vasoconstriction in the renal and mesenteric vasculature of the rat, but had opposite effects in the rat splenic vasculature indicates that the modulatory-effect of PGE-compounds on the adrenergic neuromuscular junction is species dependent and varies in different vascular beds within the same species. Prostaglandins, the release of which is evoked by several vasoactive substances including angiotensins, kinins, and adenine nucleotides, may also contribute to the regulation of vascular tone by either opposing or amplifying the vascular actions of vasoactive substances.

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Year:  1978        PMID: 23968

Source DB:  PubMed          Journal:  Fed Proc        ISSN: 0014-9446


  16 in total

1.  ACTH release induced in rats by noradrenaline is mediated by prostaglandin E2.

Authors:  T Watanabe; A Morimoto; K Morimoto; T Nakamori; N Murakami
Journal:  J Physiol       Date:  1991-11       Impact factor: 5.182

2.  Effects of prostaglandin I2 synthesized in the endothelium and in the smooth muscle on mechanical properties of the canine thoracic aorta.

Authors:  M Domae; H Kuriyama
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

3.  Multiple prejunctional actions of angiotensin II on noradrenergic transmission in the caudal artery of the rat.

Authors:  S L Cox; D F Story; J Ziogas
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

Review 4.  A hitch-hiker's guide to the galaxy of adrenoceptors.

Authors:  G M Lees
Journal:  Br Med J (Clin Res Ed)       Date:  1981-07-18

5.  Changes of vasoactive substances following embolization for renal cell carcinoma.

Authors:  T Nakada; H Koike; T Katayama
Journal:  Int Urol Nephrol       Date:  1988       Impact factor: 2.370

6.  The importance of endogenous prostaglandins other than prostacyclin, for the modulation of contractility of some rabbit blood vessels.

Authors:  U Förstermann; G Hertting; B Neufang
Journal:  Br J Pharmacol       Date:  1984-04       Impact factor: 8.739

7.  [Reduced urinary prostaglandin E2-excretion and diminished responsiveness of plasma renin activity in patients with essential hypertension (author's transl)].

Authors:  B Scherer; E Held; H H Lange; P C Weber
Journal:  Klin Wochenschr       Date:  1979-06-01

8.  Attenuation by bradykinin of adrenergically-induced vasoconstriction in the isolated perfused kidney of the rabbit: relationship to prostaglandin synthesis.

Authors:  K U Malik; A Nasjletti
Journal:  Br J Pharmacol       Date:  1979-10       Impact factor: 8.739

9.  Effects of aging on ATP sensitive K(+) channels and on prostanoid production in the rat mesenteric bed.

Authors:  E C Feleder; H A Peredo; V E Mendizábal; E Adler-Graschinsky
Journal:  Age (Omaha)       Date:  1998-10

10.  Angiotensin III-induced modulation of neurogenic responses in the rabbit vas deferens and portal vein.

Authors:  G J Trachte; E J Sybertz; M Michener; S B Binder; M J Peach
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-07       Impact factor: 3.000

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