Literature DB >> 23966399

TMPRSS2 is an activating protease for respiratory parainfluenza viruses.

Masako Abe1, Maino Tahara, Kouji Sakai, Hiromi Yamaguchi, Kazuhiko Kanou, Kazuya Shirato, Miyuki Kawase, Masahiro Noda, Hirokazu Kimura, Shutoku Matsuyama, Hideo Fukuhara, Katsumi Mizuta, Katsumi Maenaka, Yasushi Ami, Mariko Esumi, Atsushi Kato, Makoto Takeda.   

Abstract

Here, we show that human parainfluenza viruses and Sendai virus (SeV), like other respiratory viruses, use TMPRSS2 for their activation. The membrane fusion proteins of respiratory viruses often possess serine and glutamine residues at the P2 and P3 positions, respectively, but these residues were not critical for cleavage by TMPRSS2. However, mutations of these residues affected SeV growth in specific epithelial cell lines, suggesting the importance of these residues for SeV replication in epithelia.

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Year:  2013        PMID： 23966399      PMCID： PMC3807344          DOI： 10.1128/JVI.01490-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

Review 1.  Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes.

Authors:  J D Hooper; J A Clements; J P Quigley; T M Antalis
Journal:  J Biol Chem       Date:  2001-01-12       Impact factor: 5.157

2.  Mini-plasmin found in the epithelial cells of bronchioles triggers infection by broad-spectrum influenza A viruses and Sendai virus.

Authors:  M Murakami; T Towatari; M Ohuchi; M Shiota; M Akao; Y Okumura; M A Parry; H Kido
Journal:  Eur J Biochem       Date:  2001-05

3.  High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays.

Authors:  Dhaval N Gosalia; Cleo M Salisbury; Jonathan A Ellman; Scott L Diamond
Journal:  Mol Cell Proteomics       Date:  2005-02-10       Impact factor: 5.911

4.  Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response.

Authors:  Ilona Glowacka; Stephanie Bertram; Marcel A Müller; Paul Allen; Elizabeth Soilleux; Susanne Pfefferle; Imke Steffen; Theodros Solomon Tsegaye; Yuxian He; Kerstin Gnirss; Daniela Niemeyer; Heike Schneider; Christian Drosten; Stefan Pöhlmann
Journal:  J Virol       Date:  2011-02-16       Impact factor: 5.103

5.  Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.

Authors:  Miyuki Kawase; Kazuya Shirato; Lia van der Hoek; Fumihiro Taguchi; Shutoku Matsuyama
Journal:  J Virol       Date:  2012-04-11       Impact factor: 5.103

6.  A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.

Authors:  Ana Shulla; Taylor Heald-Sargent; Gitanjali Subramanya; Jincun Zhao; Stanley Perlman; Tom Gallagher
Journal:  J Virol       Date:  2010-11-10       Impact factor: 5.103

7.  TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.

Authors:  Stephanie Bertram; Ilona Glowacka; Paulina Blazejewska; Elizabeth Soilleux; Paul Allen; Simon Danisch; Imke Steffen; So-Young Choi; Youngwoo Park; Heike Schneider; Klaus Schughart; Stefan Pöhlmann
Journal:  J Virol       Date:  2010-07-14       Impact factor: 5.103

8.  Profiling serine protease substrate specificity with solution phase fluorogenic peptide microarrays.

Authors:  Dhaval N Gosalia; Cleo M Salisbury; Dustin J Maly; Jonathan A Ellman; Scott L Diamond
Journal:  Proteomics       Date:  2005-04       Impact factor: 3.984

9.  Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2.

Authors:  Yuta Shirogane; Makoto Takeda; Masaharu Iwasaki; Nobuhisa Ishiguro; Hiroki Takeuchi; Yuichiro Nakatsu; Maino Tahara; Hideaki Kikuta; Yusuke Yanagi
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

Review 10.  Type II transmembrane serine proteases in cancer and viral infections.

Authors:  So-Young Choi; Stephanie Bertram; Ilona Glowacka; Young Woo Park; Stefan Pöhlmann
Journal:  Trends Mol Med       Date:  2009-07-04       Impact factor: 11.951
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  24 in total

1.  Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay.

Authors:  Hatem A Elshabrawy; Jilao Fan; Christine S Haddad; Kiira Ratia; Christopher C Broder; Michael Caffrey; Bellur S Prabhakar
Journal:  J Virol       Date:  2014-02-05       Impact factor: 5.103

2.  The host protease TMPRSS2 plays a major role in in vivo replication of emerging H7N9 and seasonal influenza viruses.

Authors:  Kouji Sakai; Yasushi Ami; Maino Tahara; Toru Kubota; Masaki Anraku; Masako Abe; Noriko Nakajima; Tsuyoshi Sekizuka; Kazuya Shirato; Yuriko Suzaki; Akira Ainai; Yuichiro Nakatsu; Kazuhiko Kanou; Kazuya Nakamura; Tadaki Suzuki; Katsuhiro Komase; Eri Nobusawa; Katsumi Maenaka; Makoto Kuroda; Hideki Hasegawa; Yoshihiro Kawaoka; Masato Tashiro; Makoto Takeda
Journal:  J Virol       Date:  2014-03-05       Impact factor: 5.103

3.  TMPRSS12 Is an Activating Protease for Subtype B Avian Metapneumovirus.

Authors:  Bingling Yun; Yao Zhang; Yongzhen Liu; Xiaolu Guan; Yongqiang Wang; Xiaole Qi; Hongyu Cui; Changjun Liu; Yanping Zhang; Honglei Gao; Li Gao; Kai Li; Yulong Gao; Xiaomei Wang
Journal:  J Virol       Date:  2016-11-28       Impact factor: 5.103

4.  Kallistatin ameliorates influenza virus pathogenesis by inhibition of kallikrein-related peptidase 1-mediated cleavage of viral hemagglutinin.

Authors:  Chia-Hsing Leu; Mei-Lin Yang; Nai-Hui Chung; Yen-Jang Huang; Yu-Chu Su; Yi-Cheng Chen; Chia-Cheng Lin; Gia-Shing Shieh; Meng-Ya Chang; Shainn-Wei Wang; Yao Chang; Julie Chao; Lee Chao; Chao-Liang Wu; Ai-Li Shiau
Journal:  Antimicrob Agents Chemother       Date:  2015-07-06       Impact factor: 5.191

5.  Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.

Authors:  Mizuki Yamamoto; Shutoku Matsuyama; Xiao Li; Makoto Takeda; Yasushi Kawaguchi; Jun-Ichiro Inoue; Zene Matsuda
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

Review 6.  Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants.

Authors:  Megan Meyer; Ilona Jaspers
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2015-04-17       Impact factor: 5.464

Review 7.  Antivirals targeting paramyxovirus membrane fusion.

Authors:  Erik M Contreras; Isaac Abrrey Monreal; Martin Ruvalcaba; Victoria Ortega; Hector C Aguilar
Journal:  Curr Opin Virol       Date:  2021-09-27       Impact factor: 7.090

8.  TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice.

Authors:  Carolin Tarnow; Géraldine Engels; Annika Arendt; Folker Schwalm; Hanna Sediri; Annette Preuss; Peter S Nelson; Wolfgang Garten; Hans-Dieter Klenk; Gülsah Gabriel; Eva Böttcher-Friebertshäuser
Journal:  J Virol       Date:  2014-02-12       Impact factor: 5.103

9.  Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses.

Authors:  Michihito Sasaki; Yukari Itakura; Mai Kishimoto; Koshiro Tabata; Kentaro Uemura; Naoto Ito; Makoto Sugiyama; Christida E Wastika; Yasuko Orba; Hirofumi Sawa
Journal:  J Virol       Date:  2021-03-24       Impact factor: 6.549

10.  TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.

Authors:  Pawel Zmora; Anna-Sophie Moldenhauer; Heike Hofmann-Winkler; Stefan Pöhlmann
Journal:  PLoS One       Date:  2015-09-17       Impact factor: 3.240
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