Literature DB >> 23966396

Varicella-zoster virus open reading frame 48 encodes an active nuclease.

Niklaus H Mueller1, Don Gilden, Randall J Cohrs.   

Abstract

Based on a DNA sequence and relative genomic position similar to those other herpesviruses, varicella-zoster virus (VZV) open reading frame 48 (ORF48) is predicted to encode an alkaline nuclease. Here we report the cloning, expression, purification, and characterization of recombinant VZV ORF48 protein and a VZV ORF48 point mutation (T172P). Protein encoded by wild-type ORF48, but not mutant protein, displayed both endo- and exonuclease activity, identifying ORF48 as a potential therapeutic target in VZV disease since efficient viral replication requires viral nuclease activity.

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Year:  2013        PMID： 23966396      PMCID： PMC3807315          DOI： 10.1128/JVI.01879-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Herpes Zoster Ophthalmicus: Report of Cases and a Review of the Literature.

Authors:  A E Edgerton
Journal:  Trans Am Ophthalmol Soc       Date:  1942

2.  The exonuclease activity of HSV-1 UL12 is required for in vivo function.

Authors:  J N Goldstein; S K Weller
Journal:  Virology       Date:  1998-05-10       Impact factor: 3.616

3.  Regulation of lambda exonuclease. I. Properties of lambda exonuclease purified from lysogens of lambda T11 and wild type.

Authors:  C M Radding
Journal:  J Mol Biol       Date:  1966-07       Impact factor: 5.469

4.  The herpes simplex virus type 1 alkaline nuclease is not essential for viral DNA synthesis: isolation and characterization of a lacZ insertion mutant.

Authors:  S K Weller; M R Seghatoleslami; L Shao; D Rowse; E P Carmichael
Journal:  J Gen Virol       Date:  1990-12       Impact factor: 3.891

Review 5.  The varicella-zoster virus genome.

Authors:  Jeffrey I Cohen
Journal:  Curr Top Microbiol Immunol       Date:  2010       Impact factor: 4.291

6.  Structural modelling and mutagenesis of human cytomegalovirus alkaline nuclease UL98.

Authors:  Alison L Kuchta; Hardik Parikh; Yali Zhu; Glen E Kellogg; Deborah S Parris; Michael A McVoy
Journal:  J Gen Virol       Date:  2011-09-07       Impact factor: 3.891

7.  Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus.

Authors:  Mee Yon Lee; Kyu Seop Kim; Won Ki Lee
Journal:  Ocul Immunol Inflamm       Date:  2011-06       Impact factor: 3.070

8.  Herpes simplex virus 1 alkaline nuclease is required for efficient egress of capsids from the nucleus.

Authors:  L Shao; L M Rapp; S K Weller
Journal:  Virology       Date:  1993-09       Impact factor: 3.616

9.  Comprehensive analysis of varicella-zoster virus proteins using a new monoclonal antibody collection.

Authors:  Tihana Lenac Roviš; Susanne M Bailer; Venkata R Pothineni; Werner J D Ouwendijk; Hrvoje Šimić; Marina Babić; Karmela Miklić; Suzana Malić; Marieke C Verweij; Armin Baiker; Orland Gonzalez; Albrecht von Brunn; Ralf Zimmer; Klaus Früh; Georges M G M Verjans; Stipan Jonjić; Jürgen Haas
Journal:  J Virol       Date:  2013-04-17       Impact factor: 5.103

Review 10.  Varicella-zoster virus human ganglionic latency: a current summary.

Authors:  Peter G E Kennedy; Randall J Cohrs
Journal:  J Neurovirol       Date:  2010-09-27       Impact factor: 3.739
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  1 in total

1.  Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.

Authors:  Brett A Duguay; Holly A Saffran; Alina Ponomarev; Shayla A Duley; Heather E Eaton; James R Smiley
Journal:  J Virol       Date:  2013-12-26       Impact factor: 5.103
  1 in total

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