Literature DB >> 23966394

Effects of cellular activation on anti-HIV-1 restriction factor expression profile in primary cells.

Rui André Saraiva Raposo1, Mohamed Abdel-Mohsen, Miroslawa Bilska, David C Montefiori, Douglas F Nixon, Satish K Pillai.   

Abstract

Expression of cell-intrinsic antiviral factors suppresses HIV-1 replication. We hypothesized that cellular activation modulates host restriction and susceptibility to HIV-1 infection. We measured the gene expression of 34 antiviral factors in healthy peripheral blood mononuclear cells (PBMC). Cellular activation induced expression of interferon-stimulated gene 15 (ISG15), tripartite motif 5α (TRIM5α), bone marrow stromal cell antigen 2 (BST-2)/tetherin, and certain apolipoprotein B mRNA editing enzyme 3 (APOBEC3) family members. Expression of RTF1, RNA polymerase II-associated factor 1 (PAF1), TRIM11, TRIM26, and BST-2/tetherin correlated with decreased HIV-1 infectivity. This report demonstrates synchronous effects of activation-induced antiviral genes on HIV-1 infectivity, providing candidates for pharmacological manipulation.

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Year:  2013        PMID： 23966394      PMCID： PMC3807358          DOI： 10.1128/JVI.02128-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  44 in total

1.  Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo.

Authors:  Satish K Pillai; Mohamed Abdel-Mohsen; John Guatelli; Mark Skasko; Alexander Monto; Katsuya Fujimoto; Steven Yukl; Warner C Greene; Helen Kovari; Andri Rauch; Jacques Fellay; Manuel Battegay; Bernard Hirschel; Andrea Witteck; Enos Bernasconi; Bruno Ledergerber; Huldrych F Günthard; Joseph K Wong
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-06       Impact factor: 11.205

2.  SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

Authors:  Hanna-Mari Baldauf; Xiaoyu Pan; Elina Erikson; Sarah Schmidt; Waaqo Daddacha; Manja Burggraf; Kristina Schenkova; Ina Ambiel; Guido Wabnitz; Thomas Gramberg; Sylvia Panitz; Egbert Flory; Nathaniel R Landau; Serkan Sertel; Frank Rutsch; Felix Lasitschka; Baek Kim; Renate König; Oliver T Fackler; Oliver T Keppler
Journal:  Nat Med       Date:  2012-11       Impact factor: 53.440

Review 3.  The restriction factors of human immunodeficiency virus.

Authors:  Reuben S Harris; Judd F Hultquist; David T Evans
Journal:  J Biol Chem       Date:  2012-10-05       Impact factor: 5.157

4.  Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

Authors:  Stuart J D Neil; Trinity Zang; Paul D Bieniasz
Journal:  Nature       Date:  2008-01-16       Impact factor: 49.962

5.  Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction.

Authors:  Eric W Refsland; Mark D Stenglein; Keisuke Shindo; John S Albin; William L Brown; Reuben S Harris
Journal:  Nucleic Acids Res       Date:  2010-03-22       Impact factor: 16.971

6.  APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication.

Authors:  Qin Yu; Darlene Chen; Renate König; Roberto Mariani; Derya Unutmaz; Nathaniel R Landau
Journal:  J Biol Chem       Date:  2004-10-04       Impact factor: 5.157

7.  The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.

Authors:  Matthew Stremlau; Christopher M Owens; Michel J Perron; Michael Kiessling; Patrick Autissier; Joseph Sodroski
Journal:  Nature       Date:  2004-02-26       Impact factor: 49.962

8.  Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.

Authors:  Kasia Hrecka; Caili Hao; Magda Gierszewska; Selene K Swanson; Malgorzata Kesik-Brodacka; Smita Srivastava; Laurence Florens; Michael P Washburn; Jacek Skowronski
Journal:  Nature       Date:  2011-06-29       Impact factor: 49.962

9.  A whole genome screen for HIV restriction factors.

Authors:  Li Liu; Nidia M M Oliveira; Kelly M Cheney; Corinna Pade; Hanna Dreja; Ann-Marie H Bergin; Viola Borgdorff; David H Beach; Cleo L Bishop; Matthias T Dittmar; Aine McKnight
Journal:  Retrovirology       Date:  2011-11-14       Impact factor: 4.602

10.  Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

Authors:  Jesus F Salazar-Gonzalez; Maria G Salazar; Brandon F Keele; Gerald H Learn; Elena E Giorgi; Hui Li; Julie M Decker; Shuyi Wang; Joshua Baalwa; Matthias H Kraus; Nicholas F Parrish; Katharina S Shaw; M Brad Guffey; Katharine J Bar; Katie L Davis; Christina Ochsenbauer-Jambor; John C Kappes; Michael S Saag; Myron S Cohen; Joseph Mulenga; Cynthia A Derdeyn; Susan Allen; Eric Hunter; Martin Markowitz; Peter Hraber; Alan S Perelson; Tanmoy Bhattacharya; Barton F Haynes; Bette T Korber; Beatrice H Hahn; George M Shaw
Journal:  J Exp Med       Date:  2009-06-01       Impact factor: 14.307
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  21 in total

1.  Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages.

Authors:  Karen Trang; Rui André Raposo; Margaret M Lowe; Elisabeth R Krow-Lucal; Wes Yonemoto; Vinicius D Cabido; Devi SenGupta; Joseph M McCune
Journal:  Viral Immunol       Date:  2017-02-02       Impact factor: 2.257

2.  Short Communication: Expression of Host Restriction Factors by Memory CD4+ T Cells Differs Between Healthy Donors and HIV-1-Infected Individuals with Effective Antiretroviral Therapy.

Authors:  Nathaniel D Bachtel; Greta A Beckerle; Talia M Mota; Miguel de Mulder Rougvie; Rui André Saraiva Raposo; R Brad Jones; Douglas F Nixon; Richard Apps
Journal:  AIDS Res Hum Retroviruses       Date:  2018-10-16       Impact factor: 2.205

3.  IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis.

Authors:  Rui André Saraiva Raposo; Miguel de Mulder Rougvie; Dominic Paquin-Proulx; Phillip M Brailey; Vinicius D Cabido; Paul M Zdinak; Allison S Thomas; Szu-Han Huang; Greta A Beckerle; Richard B Jones; Douglas F Nixon
Journal:  JCI Insight       Date:  2017-01-12

4.  Host genetics contributes to the effectiveness of dendritic cell-based HIV immunotherapy.

Authors:  Edione C Reis; Lais T da Silva; Wanessa C da Silva; Alexandre Rios; Alberto J Duarte; Telma M Oshiro; Sergio Crovella; Alessandra Pontillo
Journal:  Hum Vaccin Immunother       Date:  2018-05-17       Impact factor: 3.452

5.  Short Communication: Expression of APOBEC3G and Interferon Gamma in Pleural Fluid Mononuclear Cells from HIV/TB Dual Infected Subjects.

Authors:  Zahra Toossi; Qinglai Meng; Htin Aung; Shigou Liu; Harriet Mayanja-Kizza; Christina S Hirsch
Journal:  AIDS Res Hum Retroviruses       Date:  2015-06-04       Impact factor: 2.205

6.  Genome-Wide Analyses Reveal Gene Influence on HIV Disease Progression and HIV-1C Acquisition in Southern Africa.

Authors:  Wen Xie; Denis Agniel; Andrey Shevchenko; Sergey V Malov; Anton Svitin; Nikolay Cherkasov; Marianna K Baum; Adriana Campa; Simani Gaseitsiwe; Hermann Bussmann; Joseph Makhema; Richard Marlink; Vladimir Novitsky; Tun-Hou Lee; Tianxi Cai; Stephen J O'Brien; M Essex
Journal:  AIDS Res Hum Retroviruses       Date:  2017-04-06       Impact factor: 2.205

7.  Dynamic Modulation of Expression of Lentiviral Restriction Factors in Primary CD4+ T Cells following Simian Immunodeficiency Virus Infection.

Authors:  Andrew R Rahmberg; Premeela A Rajakumar; James M Billingsley; R Paul Johnson
Journal:  J Virol       Date:  2017-03-13       Impact factor: 5.103

8.  Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo.

Authors:  Mohamed Abdel-Mohsen; Xutao Deng; Teri Liegler; John C Guatelli; Mohamed S Salama; Hussam El-din A Ghanem; Andri Rauch; Bruno Ledergerber; Steven G Deeks; Huldrych F Günthard; Joseph K Wong; Satish K Pillai
Journal:  J Virol       Date:  2013-10-23       Impact factor: 5.103

9.  Antiviral gene expression in psoriasis.

Authors:  R A Raposo; R Gupta; M Abdel-Mohsen; M Dimon; M Debbaneh; W Jiang; V A York; K S Leadabrand; G Brown; M Malakouti; S Arron; P J Kuebler; J J Wu; S K Pillai; D F Nixon; W Liao
Journal:  J Eur Acad Dermatol Venereol       Date:  2015-03-23       Impact factor: 6.166

10.  Dynamic regulation of host restriction factor expression over the course of HIV-1 infection in vivo.

Authors:  Rui André Saraiva Raposo; Mohamed Abdel-Mohsen; Xutao Deng; Frederick M Hecht; Christopher D Pilcher; Satish K Pillai; Douglas F Nixon
Journal:  J Virol       Date:  2014-07-16       Impact factor: 5.103
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