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Literature DB >> 23966391

Dynamics of cytokine/chemokine responses in intestinal CD4+ and CD8+ T Cells during Acute Simian Immunodeficiency Virus Infection.

Carys S Kenway-Lynch¹, Arpita Das, Diganta Pan, Andrew A Lackner, Bapi Pahar.

Abstract

Loss of intestinal CD4(+) T cells was associated with decreased production of several T-helper 1 (TH1) and TH2 cytokines and increased production of interleukin 17 (IL-17), gamma interferon (IFN-γ), CCL4, and granulocyte-macrophage colony-stimulating factor (GM-CSF) by CD8(+) T cells 21 days after simian immunodeficiency virus (SIV) infection in rhesus macaques. Shifting of mucosal TH1 to TH2 or T-cytotoxic 1 (TC1) to TC2 cytokine profiles was not evident. Additionally, both CD4(+) and CD8(+) T cells showed upregulation of macrophage migration inhibition factor (MIF) and basic fibroblast growth factor (FGF-basic) cytokines that have been linked to HIV disease progression.

Entities: Disease Gene Species

Mesh：

Substances：
Cytokines

Year: 2013 PMID： 23966391 PMCID： PMC3807351 DOI： 10.1128/JVI.01750-13

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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