Literature DB >> 23966298

Skinflammation and drug toxicity--a delicate balance.

Mario E Lacouture1, Ulrich Rodeck.   

Abstract

Loss of epidermal growth factor receptor function in epidermal keratinocytes triggers a disfiguring acneiform rash through the coordinate activation of innate and adaptive immune defense mechanisms (Mascia et al. and Lichtenberger et al., this issue).

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Year:  2013        PMID： 23966298     DOI： 10.1126/scitranslmed.3006993

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  4 in total

1.  Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial.

Authors:  William N William; Vassiliki Papadimitrakopoulou; J Jack Lee; Li Mao; Ezra E W Cohen; Heather Y Lin; Ann M Gillenwater; Jack W Martin; Mark W Lingen; Jay O Boyle; Dong M Shin; Nadarajah Vigneswaran; Nancy Shinn; John V Heymach; Ignacio I Wistuba; Ximing Tang; Edward S Kim; Pierre Saintigny; Elizabeth A Blair; Timothy Meiller; J Silvio Gutkind; Jeffrey Myers; Adel El-Naggar; Scott M Lippman
Journal:  JAMA Oncol       Date:  2016-02       Impact factor: 31.777

2.  Reducing Skin Toxicities from EGFR Inhibitors with Topical BRAF Inhibitor Therapy.

Authors:  Mario E Lacouture; Zev A Wainberg; Anisha B Patel; Milan J Anadkat; Salomon M Stemmer; Einat Shacham-Shmueli; Egmidio Medina; Galit Zelinger; Noa Shelach; Antoni Ribas
Journal:  Cancer Discov       Date:  2021-04-28       Impact factor: 39.397

3.  Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.

Authors:  Yariv Mazor; Kris F Sachsenmeier; Chunning Yang; Anna Hansen; Jessica Filderman; Kathy Mulgrew; Herren Wu; William F Dall'Acqua
Journal:  Sci Rep       Date:  2017-01-09       Impact factor: 4.379

4.  Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists.

Authors:  Shawn G Kwatra; Emily Boozalis; Amy H Huang; Cory Nanni; Raveena Khanna; Kyle A Williams; Yevgeniy R Semenov; Callie M Roberts; Robert F Burns; Madison Krischak; Madan M Kwatra
Journal:  Medicines (Basel)       Date:  2019-12-09
  4 in total

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