CONTEXT: Estrogen deficiency, systemic low-grade inflammation, and reduction of adrenal gland function have central roles in noncommunicable chronic disease (NCD) development. With angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, the deletion variant (DD) is related to higher levels of circulating angiotensin II than I allele carriers (II/ID), which might interact with all of these molecular pathways to increase NCDs risk. On the other hand, physical exercise counteracts the occurrence of NCDs, potentially acting on the same pathways. OBJECTIVES: The aim of the study was to investigate the effects of walking training on adrenal steroid and cytokine levels and on cardiovascular parameters in postmenopausal women with ACE I/D genotypes. METHODS: Thirty-six (DD = 15, II/ID = 21) sedentary postmenopausal women (mean age, 56 ± 4 y) participated in a 13-week program of walking training at moderate intensity. Heart rate, blood pressure, double product, TNF-α, dehydroepiandrosterone sulfate (DHEA-S), and cortisol were evaluated before and after the intervention program. RESULTS: Before walking training, the ACE DD genotype showed significantly higher TNF-α (P = .007) and lower DHEA-S concentrations (P = .022) than the ACE II/ID individuals. After walking training, both subgroups significantly decreased TNF-α plasma levels and cortisol/DHEA-S ratio (P = .001 and P = .016, respectively) and significantly increased DHEA-S levels (P < .001). Moreover, all the cardiovascular parameters were significantly reduced in the ACE DD participants (P ≤ .05), whereas the ACE I-allele carriers showed a decrease in heart rate (P ≤ .05) and the double product (P ≤ .05). CONCLUSION: ACE I/D polymorphism is linked to different adrenal steroid and cytokine levels, and ACE I-allele carriers show a better adrenal activity and systemic inflammatory profile. The introduction of walking training positively influences the menopause immune-neuroendocrine changes, independent of ACE I/D genotype.
CONTEXT: Estrogen deficiency, systemic low-grade inflammation, and reduction of adrenal gland function have central roles in noncommunicable chronic disease (NCD) development. With angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, the deletion variant (DD) is related to higher levels of circulating angiotensin II than I allele carriers (II/ID), which might interact with all of these molecular pathways to increase NCDs risk. On the other hand, physical exercise counteracts the occurrence of NCDs, potentially acting on the same pathways. OBJECTIVES: The aim of the study was to investigate the effects of walking training on adrenal steroid and cytokine levels and on cardiovascular parameters in postmenopausal women with ACE I/D genotypes. METHODS: Thirty-six (DD = 15, II/ID = 21) sedentary postmenopausal women (mean age, 56 ± 4 y) participated in a 13-week program of walking training at moderate intensity. Heart rate, blood pressure, double product, TNF-α, dehydroepiandrosterone sulfate (DHEA-S), and cortisol were evaluated before and after the intervention program. RESULTS: Before walking training, the ACE DD genotype showed significantly higher TNF-α (P = .007) and lower DHEA-S concentrations (P = .022) than the ACE II/ID individuals. After walking training, both subgroups significantly decreased TNF-α plasma levels and cortisol/DHEA-S ratio (P = .001 and P = .016, respectively) and significantly increased DHEA-S levels (P < .001). Moreover, all the cardiovascular parameters were significantly reduced in the ACE DD participants (P ≤ .05), whereas the ACE I-allele carriers showed a decrease in heart rate (P ≤ .05) and the double product (P ≤ .05). CONCLUSION:ACE I/D polymorphism is linked to different adrenal steroid and cytokine levels, and ACE I-allele carriers show a better adrenal activity and systemic inflammatory profile. The introduction of walking training positively influences the menopause immune-neuroendocrine changes, independent of ACE I/D genotype.
Authors: Pascal Izzicupo; Maria A D'Amico; Andrea Di Blasio; Giorgio Napolitano; Fabio Y Nakamura; Angela Di Baldassarre; Barbara Ghinassi Journal: Front Endocrinol (Lausanne) Date: 2017-12-21 Impact factor: 5.555
Authors: Pascal Izzicupo; Andrea Di Blasio; Andrea Di Credico; Giulia Gaggi; Anastasios Vamvakis; Giorgio Napolitano; Fabrizio Ricci; Sabina Gallina; Barbara Ghinassi; Angela Di Baldassarre Journal: Int J Environ Res Public Health Date: 2020-04-28 Impact factor: 3.390
Authors: Angela Di Baldassarre; Maria A D'Amico; Pascal Izzicupo; Giulia Gaggi; Simone Guarnieri; Maria A Mariggiò; Ivana Antonucci; Barbara Corneo; Dario Sirabella; Liborio Stuppia; Barbara Ghinassi Journal: Sci Rep Date: 2018-08-13 Impact factor: 4.379
Authors: Pascal Izzicupo; Andrea Di Blasio; Andrea Di Credico; Barbara Ghinassi; Laura Capranica; Giorgio Napolitano; Angela Di Baldassarre; Elisabetta Modestini; Mario Di Pietro Journal: Front Sports Act Living Date: 2021-03-25
Authors: Andrea Di Credico; Giulia Gaggi; Barbara Ghinassi; Gabriele Mascherini; Cristian Petri; Riccardo Di Giminiani; Angela Di Baldassarre; Pascal Izzicupo Journal: Int J Environ Res Public Health Date: 2020-11-08 Impact factor: 3.390
Authors: Giulia Gaggi; Andrea Di Credico; Pascal Izzicupo; Silvia Sancilio; Michele Di Mauro; Giovanni Iannetti; Susanna Dolci; Giovanni Amabile; Angela Di Baldassarre; Barbara Ghinassi Journal: Int J Mol Sci Date: 2020-08-31 Impact factor: 5.923
Authors: Andrea Di Credico; Giulia Gaggi; Anastasios Vamvakis; Sofia Serafini; Barbara Ghinassi; Angela Di Baldassarre; Pascal Izzicupo Journal: Int J Environ Res Public Health Date: 2021-12-08 Impact factor: 3.390