Kebede Deribe1, Alemeshet Yami2, Amare Deribew3, Nebiyu Mesfin4, Robert Colebunders5, Jean Pierre Van Geertruyden6, Mirkuzie Woldie7, Todd Maja8. 1. Department of Epidemiology, Jimma University, Jimma, Ethiopia kebededeka@yahoo.com. 2. Department of Internal Medicine, Jimma University, Jimma, Ethiopia. 3. Department of Epidemiology, Jimma University, Jimma, Ethiopia. 4. Department of Internal Medicine, Jimma University, Jimma, Ethiopia Department of Internal Medicine, Gondar University, Gondar, Ethiopia. 5. Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium. 6. Department of Epidemiology and Social Medicine, University of Antwerp, Antwerp, Belgium. 7. Department of Health Services Management, Jimma University, Jimma, Ethiopia. 8. Department of Health Studies, UNISA, Pretoria, South Africa.
Abstract
BACKGROUND: Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB/HIV-coinfected patients. METHODS: We conducted an unmatched case-control study among a cohort of TB/HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB/HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB/HIV-coinfected patients who were alive during the end of the follow-up period. RESULTS: Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB/HIV-coinfected patients. CONCLUSION: Mortality among TB/HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.
BACKGROUND:Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB/HIV-coinfectedpatients. METHODS: We conducted an unmatched case-control study among a cohort of TB/HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB/HIV-coinfectedpatients who died during this period. For each case, we selected 3 (207) TB/HIV-coinfectedpatients who were alive during the end of the follow-up period. RESULTS: Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB/HIV-coinfectedpatients. CONCLUSION: Mortality among TB/HIV-coinfectedpatients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.
Authors: D Nakanjako; H Mayanja-Kizza; J Ouma; R Wanyenze; D Mwesigire; A Namale; J Ssempiira; J Senkusu; R Colebunders; M R Kamya Journal: Int J Tuberc Lung Dis Date: 2010-12 Impact factor: 2.373
Authors: Ako A Agbor; Jean Joel R Bigna; Claudia S Plottel; Serges Clotaire Billong; Mathurin Cyrille Tejiokem; Gabriel L Ekali; Jean Jacques N Noubiap; Roselyne Toby; Hermine Abessolo; Sinata Koulla-Shiro Journal: Arch Public Health Date: 2015-05-04
Authors: Sarah W Beckham; Chris Beyrer; Peter Luckow; Meg Doherty; Eyerusalem K Negussie; Stefan D Baral Journal: J Int AIDS Soc Date: 2016-11-08 Impact factor: 5.396
Authors: Jean Joel R Bigna; Jean Jacques N Noubiap; Ako A Agbor; Claudia S Plottel; Serge Clotaire Billong; André Patrick R Ayong; Sinata Koulla-Shiro Journal: PLoS One Date: 2015-07-27 Impact factor: 3.240