| Literature DB >> 23965132 |
Nan Lin, Zhangyi Liu, Jie Zhou, Shihua Wang, Joy Fleming.
Abstract
The prevalence of drug-resistance in Mycobacterium tuberculosis is already having a negative impact on the control of tuberculosis. We report the draft genome sequences of two super-extensively drug-resistant M. tuberculosis isolates from China, FJ05194 (lineage 2) and GuangZ0019 (lineage 4), and compare them with the H37Rv reference strain to identify possible sources of genetic variation associated with their extensive drug resistance. Our results suggest that their extensive drug resistance probably results from the stepwise accumulation of resistances to individual drugs.Entities:
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Year: 2013 PMID: 23965132 DOI: 10.1111/1574-6968.12238
Source DB: PubMed Journal: FEMS Microbiol Lett ISSN: 0378-1097 Impact factor: 2.742