| Literature DB >> 2396476 |
M L Joffret1, S Morgeaux, C Laclerc, D Oth, C Zanetti, P Sureau, P Perrin.
Abstract
The present report demonstrates that liposomes increase the interleukin-2 (IL-2) dependent proliferation of cytotoxic T-lymphocyte line (CTLL) cells used for the measurement of IL-2 activity. This effect was better observed with suboptimal doses of IL-2 and low concentrations of lipids. The increased IL-2 dependent proliferation is not due to a direct effect of liposomes on CTLL cells but rather to an interaction between IL-2 and liposomes. An interaction between IL-2 and components of fetal calf serum is also demonstrated. The results indicate that liposomes may interfere with IL-2 bioassay but also show the possibility of potentiating IL-2 activity for therapeutic purposes.Entities:
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Year: 1990 PMID： 2396476 DOI： 10.1016/0264-410x(90)90099-8
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641